- Etiology, pathogenesis, clinical features, points of convergence and
differences in -
- minimal cognitive impairment (MCI)
- Alzheimer's disease (AD) including also non-cognitive aspects
- vascular dementia
- cerebral amyloid angiopathy (CAA)
- Parkinson's disease (PD), PD dementia, atypical PD
- Non motor symptoms in PD
- Lewy body dementia (LBD)
- frontotemporal dementia (FTD)
- movement disorders other than PD (Tics, Restless Legs Syndrome,
Dystonia)
- schizophrenia
- neurodevelopment and neurodegeneration
- Genetics of AD and PD
- Neurogenetics of AD, PD, FTD; genetic basis for responsiveness to
approved drugs and pharmacogenomics
- Epidemiology and pharmacoeconomics in dementia and PD
- Biomarkers, diagnostics and genetic aspects of neurodegenerative diseases
- Neuroimaging - its role in early diagnosis and evaluation of clinical
trials in MCI, AD, PD, LBD
- Functional neuroimaging in PD and other movement disorders
- Leading hypotheses on neurodegeneration, major risk factors and culprits
in neurodegenerative diseases such as AD, PD, LBD, CAA, FTD
- Physiological and pathological role of β-amyloid, intracellular
β-amyloid, its precursors, β-amyloid modulation and removal
- Tau and mechanistic aspects
- Oxidative stress, apolipoprotein-E, axonal transport and others; mechanistic
aspects in neurodegeneration
- AD, PD, LBD, FTD: Animal models
- Potential disease modification in AD (α -, β - and γ-
secretases as targets; prevention of β -amyloid aggregation)
- Treatment and potential disease modification in AD, CAA {direct and
receptor-mediated modulation of kinases involved in the etiopathogenesis)
- Cholinergic treatments in neurodegenerative diseases via cholinomimetics
(cholinesterase inhibitors, cholinergic agonists and others)
- Role of cholesterol in β -amyloid modulation - basic and therapeutic
aspects in AD
- Low molecular weight glycosaminoglycans and β-sheet breakers
as potential agents in the treatment of neurodegenerative disorders
- Immunotherapies and related strategies in AD
- Mechanism and treatment strategies in PD, PD dementia and atypical
PD
- Treatment of motor and non motor symptoms and complications in PD
- Dopamine agonists and neuroprotection in PD and related disorders
- LBD: Basic and therapeutic strategies (e.g. prevention of α-synuclein
aggregation)
- α-Synuclein and proteosome system in PD and related disorders
- Stem cells, gene therapies, surgical strategies and others in neurodegenerative
diseases
- The impact of proteomics in AD/PD research
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