Session Title: Apolipoprotein-E
THE RELATIONSHIP BETWEEN RISK FACTORS FOR AD AND SERIAL POSITION EFFECTS
N. Pomara1, A. Schmeltz2, J. Sidtis1
The serial position effect is a phenomenon in which immediate recall of items at the end (recency) and beginning of a word list (primacy) is better than for mid-list items. Persons with Alzheimer's disease (AD) show disproportionate recency effects and a loss of primacy effects that are thought to reflect distinct memory systems disrupted by hippocampal lesions. Aging, female sex, and the e4-allele are established risk factors for AD. We examined if these factors produced changes in serial position in cognitively intact adults similar to those found in AD. All subjects (n=383; 151 males, mean age 69.97 + 7.76 yrs; 232 females, 68.28 + 8.73 yrs) had MMSE scores between 28-30 and were administered the Auditory Verbal Learning Test (AVLT). The sub-group of subjects with APOE genotyping consisted of 229 subjects, 161 e4 negative (69.73 + 8.85 yrs) and 68 e4 positive (69.43 + 8.57 yrs).