Session Title: Apolipoprotein-E
MIXED DEMENTIA AND APOLIPOPROTEIN E POLIMORPHISM
N. Mikhaylova1, T. Boykova2, E. Rogaev2
The aim was to compare Apolipoprotein E genotype in mixed dementia, vascular dementia (VaD) and Alzheimer's disease (AD) without vascular risk factors. 79 patients with mixed dementia were admitted to day-clinic of Moscow Alzheimer's disease center in 2005-2007. Two control groups made up 62 patients with vascular dementia and 51 patients with Alzheimer's disease without vascular affection. MRI, neuropsychological examination, EEG-mapping, ultrasonography of intracranial vessels and APO E genotyping are used. A history of stroke / TIA was found in 74.6% of VaD cases and in 37,5% of mixed dementia since in 3,9% of AD cases. MRI picture of ventricular and subarachnoidal space enlargement was common in all three groups of patients, but signs of leukoaraiosis as well as number and localization of vascular focal changes were very various in VaD and mixed dementia since were single or absent in AD. ApoE genotyping showed the most frequent presence of ApoE ε3/ε4 in mixed dementia (51.2%). ApoE ε3/ε3 was the most common in VaD (74.2%). ApoE 4/4 was three times more frequent in AD than in mixed cases (25% vs 7.0%) and was absent in VaD. Family history of old age dementia was found in 25% of patients with VaD, in 44% of patients with AD and in 40% of patients with mixed dementia. Stroke/cardiovascular diseases were much more frequent in families of VaD (75%) in comparison with AD and mixed dementia (resp. 44 and 40%).