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<title>Alzheimer's Conference / Parkinson's Conference: ADPD 2009 - Prague, March 11-15 - Poster Presentations</title>
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    <td class="content"><h1>Poster Presentations</h1>
    <P><b>Session Title:</b> Apolipoprotein-E<br><b>Presentation Date:</b> Thursday, March 12 – Friday, March 13 ,2009</P><h2 align='left'><b>SATURATED FATS DISRUPT BLOOD-BRAIN BARRIER INTEGRITY RESULTING IN BLOOD-TO-BRAIN DELIVERY OF LIPOPROTEIN-AMYLOID-BETA; IMPLICATIONS FOR ALZHEIMER'S DISEASE RISK.</b></h2>
<p align='left'>R. Takechi<sup>1</sup>, S. Galloway<sup>1</sup>, M. Pallebage-Gamarallage<sup>1</sup>, C. Wellington<sup>2</sup>, S. Dhaliwal<sup>1</sup>, R. Johnsen<sup>3</sup>, <b>J. Mamo</b><sup>1</sup><br>
<em><sup>1</sup>Curtin University, School of Public Health, Perth, Australia, <sup>2</sup>University of British Columbia, Vancouver, Canada, <sup>3</sup>Australian Neuromuscular Research Institute, Perth, Australia</em></p><br>
<p align='justify'>Some dietary fats are a risk factor for Alzheimer's disease (AD) but the mechanisms for this association are presently unknown. In this study we show in wild-type mice that chronic ingestion of saturated fats (SFA) results in blood-brain barrier (BBB) dysfunction and significant leakage into brain of dietary-derived lipoproteins enriched in amyloid-beta (Ab). In contrast, chronic ingestion of monounsaturated or polyunsaturated fatty acids had no detrimental effect on BBB integrity. Utilizing highly sensitive 3-dimenisional immuno-microscopy, we also show in a murine model of AD, a positive association of intestinal and hepatic derived apolipoprotein B lipoproteins with cerebral amyloid plaque. Collectively, the findings of this study provide a plausible explanation of how dietary fats influence AD risk. Ingestion of saturated fats may enhance peripheral delivery to brain of circulating lipoprotein-Ab and exacerbate the amyloidogenic cascade.</p>
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