Session Title: Alzheimer's Disease (AD) including Non-Cognitive Aspects
Presentation Date: Friday, March 14 – Saturday, March 15, 2009
VERBAL FLUENCY WAS RELATED TO THE CHANGES OF BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS OF DEMENTIA IN PATIENTS WITH ALZHEIMER'S DISEASE
J.-L. Fuh1, C.-F. Tsai2, S.-J. Wang1
1Taipei Veterans General Hospital, Neurological Institute, Taipei, Taiwan, Republic of China, 2Taipei Veterans General Hospital, Department of Psychiatry, Taipei, Taiwan, Republic of China
Objective: To investigate whether executive function or global cognitive function or was related to the changes of behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease (AD).
Methods: Participants with probable AD were enrolled. The patients received category verbal fluency test (CVFT) and Mini-Mental Exam (MMSE) at baseline. The BPSD was assessed by the Neuropsychiatry Inventory (NPI) at baseline and follow-up. The NPI was further classified into 4 sub-groups- hyperactive, psychosis, affective and apathy factors.
Results: 101 patients with AD were enrolled (44 males and 57 females), with a mean age of 77.3±8.1 years. In the initial evaluation, the mean MMSE was 18.6±5.6, the CVFT scores 7.1±3.9 and NPI scores 10.9±13.8. The mean follow-up duration was 10.1±4.2 months. The change of NPI scores correlated significantly with baseline CVFT (r =-0.28, p=0.005) and initial NPI scores (r=-0.24, p=0.01) but not baseline MMSE. Multiple linear regression analyses identified that baseline CVFT scores (β=-0.35, p=0.001, R2=14%) as the significant predictor to the change of NPI score, followed by the baseline NPI scores. The baseline CVFT scores was a predictor of the change of hyperactive factors (β=-0.28, p=0.006, R2=8%), the change of psychosis factor (β=-0.34, p=0.001, R2= 20%), and the change of affective factor (β=-0.28, p=0.008, R2=8%) but not the change of apathy factor.
Conclusion: CVFT but not MMSE scores were associated with the progression of BPSD at follow-up, which implies executive dysfunction might share in part pathyophsiology of BPSD.