Session Title: Alzheimer's Disease (AD) including Non-Cognitive Aspects
Presentation Date: Friday, March 14 – Saturday, March 15, 2009
PROTEIN S 100 IN AD AND VAD PATIENTS WITH MILD DEMENTIA
A. Geppert1, I. Matczynska2, J. Kaczmarek2, M. Rybczynska2
1University of Medical Sciences, Department of Neurology, Poznan, Poland, 2University of Medical Sciences, Department of Clinical Chemistry and Molecular Diagnostics, Poznan, Poland
Protein S 100 takes part in the stimulation of growing, extension and spreading of neurons and the proliferation of astrocytes and axons. It has been proved that in the process of neurons destruction protein S 100 is relased into the CSF and into the blood.
The study aimed at finding peripheral biological marker in the diagnosis in patients with mild dementia of AD and VaD.
The study was taken by the test based on the principle of electrochemiluminescence Elecsys S 100. Serum of 31 patients with mild dementia including 18 patients with AD and 13 patients with VaD and 27 control subjects was examined and concentration of protein S 100 was correlated with MMSE test among demented patients.
Medium concentration of protein S 100 in AD (0,06261±0,038 µg/l), VaD (0,06492±0,038 µg/l) and control group (0,06144±0,032 µg/l) did not differ statistically and the correlation between the concentration of protein S 100 and the autcome in MMSE test was not found. However, it was observed that the outcomes in AD group tend to be statistically significant.
At the stage of the examination the concentration of protein S 100 in serum can not be a marker of mild dementia in AD and VaD.