Session Title: Neurodevelopment and Neurodegeneration
PRENATAL EXPOSURE TO ETHANOL BUT NOT RED WINE CAUSES AGE-RELATED DEFICITS IN RODENTS
M. Fiore1, L. Aloe2, R. Mancinelli3, G. Laviola4, M. Ceccanti5
Several lines of evidences have raised the possibility that neurotrophins are abnormally regulated in the central nervous system (CNS) of animal models of chronic ethanol assumption. Neurotrophins like nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are broadly expressed in the mammalian brain playing a critical role in neuronal survival and plasticity and have been implicated as key players in learning and memory abilities in adult and aged life. The aim of this study was to investigate the effect of chronic prenatal exposure of alcohol and red wine in aged-related biological markers and aged-related behavioral response. Pregnant mice were exposed to ethanol or red wine (both at 11% vol) during pregnancy up to pup weaning. Control groups were exposed to isocaloric sucrose or water. At different time points of mouse life animals were tested for behavioral abilities and for biochemical and molecular analyses. We found that in adult and aged mice ethanol, but not red wine, causes memory deficits, reduced presence of NGF and BDNF in the cortex and hippocampus, and down-expression of ChAT reactivity in forebrain neurons. Since recent evidences have proposed that red wine may have beneficial action in neurodegenerative disorders due to the presence of compounds with strong anti-oxidant properties, our findings are consistent with prior studies that the presence of polyphenols in the red wine can protect and/or reduce long-term brain damage induced by alcohol consumption.