Poster Presentations

Thursday, March 12 – Friday, March 13 ,2009

Animal Models of Neurodegenerative Diseases and Disorders:

DIFFERENTIAL PROTEOMICS OF SYNAPTOSOMES IN ALZHEIMER´S DISEASE
A. Malinowska¹, A. Szybinska², T. Rubel³, M. Kistowski¹, F. Van Leuven⁴, M. Dadlez^1
1IBB PAS, Mass Spectrometry Laboratory, Warsaw, Poland, ²IIMCB, Laboratory of Neurodegeneration, Warsaw, Poland, ³Warsaw University of Technology, Institute of Radioelectronics, Warsaw, Poland, ⁴Katholieke Universiteit Leuven, Experimental Genetics Group, Leuven, Belgium

EFFECT OF BACE1 GENE DISRUPTION ON APP METABOLISM AND BEHAVIOR OF APP TRANSGENIC MICE WITH AND WITHOUT THE SWEDISH MUTATION
M. Staufenbiel¹, S. Rabe¹, L. Prut¹, D. Ammaturo¹, J. Reichwald¹, T. Hafner¹, D. Mathe¹, B. de Strooper², P. Saftig³, C. Wiessner¹, U. Neumann^1
1Novartis Institutes for Biomedical Research, Neuroscience Discovery, Basel, Switzerland, ²Center for Human Genetics, K. U. Leuven and VIB, Department of Human Genetics, Leuven, Belgium, ³University of Kiel, Biochemical Institute, Kiel, Germany

CHARACTERIZATION OF THE ROLE OF NOVEL SYNAPTIC CELL ADHESION MOLECULES (CAMS) IN LEARNING AND MEMORY
M. Larsen, M. Fantin, C. Sandi
Ecole Polytechnique Federale de Lausanne, Laboratory of Behavioral Genetics, Lausanne, Switzerland

NEUROTOXIC CONSEQUENCES OF INTRANEURONAL AB OLIGOMERIC AGGREGATES ON HIPPOCAMPAL DENDRITIC MORPHOLOGY IN THE 3 MONTH OLD ARCAβ TRANSGENIC MOUSE
R.F. Mervis¹, R.F. Mervis², M. Knobloch³, N. Jani⁴, S. Moradian⁴, B.A. Thomas⁵, L. Nattkemper⁶, U. Konietzko⁷, R.M. Nitsch^7
1University of South Florida College of Medicine, Center for Aging and Brain Repair, Tampa, United States, ²Neurostructural Research Labs, Inc., Tampa, United States, ³ETH Zurich Institute of Cell Biology, Zurich, Switzerland, ⁴University of South Florida, The Honors College, Tampa, United States, ⁵Neurostructural Research Labs, Inc, Tampa, United States, ⁶University of South Florida, Program in Molecular Medicine, The Graduate School, Tampa, United States, ⁷University of Zurich, Institute of Psychiatry Research, Zurich, Switzerland

AGE-DEPENDENT HIPPOCAMPAL CELL LOSS AND GLIOSIS IN A NOVEL TRANSGENIC MOUSE MODEL OF PGLU-Aβ-INDUCED NEUROTOXICITY
A. Alexandru¹, W. Jagla¹, S. Graubner¹, C. Bäuscher¹, S. Kohlmann¹, S. Schilling², S. von Hörsten³, T. Bayer⁴, H.-U. Demuth^5
1Ingenium Pharmaceuticals GmbH, Martinsried, Germany, ²Probiodrug AG, Halle (Saale), Germany, ³University of Erlangen-Nürnberg, Franz-Penzoldt-Center, Experimental Therapy, Erlangen, Germany, ⁴Division of Molecular Psychiatry, Univ. of Göttingen, Department of Psychiatry, Göttingen, Germany, ⁵Ingenium Pharmaceuticals GmbH, Martinsried; Probiodrug AG, Halle (Saale), Germany

CHARACTERIZATION OF DROSOPHILA MODELS OF ALZHEIMER'S DISEASE
C.M. Singh¹, M.B. Mahoney¹, E. Lund¹, A. Villaluz¹, J. Symonds¹, L. Diggins¹, P. O'Neil¹, E.A. Sigel², D. Keefe¹, W. Lee², M. Ahlijanian², M.G. Palfreyman^1
1Vitruven, Inc., Watertown, United States, ²EnVivo Pharmaceuticals, Inc., Watertown, United States

CHARACTERIZATION OF THE PEN-2 KNOCK OUT MOUSE
L. Bammens, A. Herreman, B. De Strooper
KuLeuven, Human Genetics, Leuven, Belgium

SR-BI REGULATES CNS APOE LEVELS AND AGGRAVATES MEMORY DEFICITS WITHOUT MODIFYING AMYLOID PLAQUE FORMATION IN ALZHEIMER TRANSGENIC MICE
K. Thanopoulou¹, A. Fragkouli², F. Stylianopoulou³, S. Georgopoulos^1
1Biomedical Research Institute, Academy of Athens, Athens, Greece, ²NCSR Demokritos, Athens, Greece, ³School of Health Sciences, University of Athens, Athens, Greece

AGE-INDEPENDENT IMPAIRMENT IN FORGETTING OF SPATIAL MEMORY IN PDAPP MICE (LINE 2613) AND ITS RELATIONSHIP TO BETA-AMYLOID LEVELS
S. Daumas¹, R. Moller², J. Tulloch¹, D. Games², R.G. Morris^1
1University of Edinburgh, Centre for Cognitive and Neural Systems, Edinburgh, United Kingdom, ²Elan Pharmaceuicals, South San Francisco, United States

DEPRIVATION-INDUCED DENDRITIC SHRINKAGE IS OPPOSITELY AFFECTED BY THE EXPRESSION OF WILD-TYPE AND MUTATED HUMAN AMYLOID PRECURSOR PROTEIN
A. Alpar¹, N. Naumann², U. Ueberham², T. Arendt², U. Gärtner^2
1Semmelweis University, Department of Anatomy, Histology and Embryology, Budapest, Hungary, ²Universität Leipzig, Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research, Leipzig, Germany

ALTERED GENE EXPRESSION PROFILES IN APP_V717I-CT100 TRANSGENIC MICE
T.-Y. Ha, K.-A. Chang, Y.-H. Suh
Seoul National University College of Medicine, Department of Pharmacology, Seoul, Korea, Republic of

EXOGENOUS INDUCTION OF PROTEIN AGGREGATION IN MOUSE MODELS OF DIFFERENT NEURODEGENERATIVE DISEASES
C. Duma¹, F. Langer¹, H. Schell², M.C. Herzig¹, T. Bolmont¹, P.J. Kahle², M. Staufenbiel³, L.C. Walker⁴, M. Jucker¹, Y.S. Eisele^1
1Hertie-Institute for Clinical Brain Research, Cellular Neurology, Tübingen, Germany, ²Hertie-Institute for Clinical Brain Research, Neurodegeneration, Tübingen, Germany, ³Novartis Pharma, Basel, Switzerland, ⁴Yerkes Center and Department of Neurology, Emory University, Atlanta, United States

CHANGES IN SPINE MORPHOLOGY BUT NOT SPINE DENSITY OCCUR WITH AGE IN TG2576 AD MICE
D.L. Dickstein, H. Brautigam, Z.A. Evans, P.R. Hof
Mount Sinai School of Medicine, Department of Neuroscience, New York, United States

TRANSGENIC AND ADENOVIRUS-BASED MODELS FOR ALZHEIMER´S DISEASE: OLD PROBLEM, NEW VIEWS
F. Van Leuven¹, T. Jaworski¹, I. Dewachter¹, S. Kügler^2
1Experimental Genetics Group - KULeuven, Leuven, Belgium, ²Dept. Neurology, Göttingen, Germany

INFLAMMATORY REACTION ASSOCIATED WITH INTRANEURONAL Aβ-OLIGOMERS AND COGNITIVE IMPAIRMENT PRIOR TO PLAQUE DEPOSITION IN A NEW ALZHEIMER'S TRANSGENIC MODEL
M.T. Ferretti¹, M.A. Bruno¹, V. Partridge¹, W. Leon¹, A. Ducatenzeiler¹, C.G. Glabe², W.L. Klein³, A.C. Cuello^1
1McGill University, Pharmacology and Therapeutics, Montreal, Canada, ²University of California, Irvine, United States, ³Northwestern University, Evanston, United States

SYNTHETIC AB_1-40 OLIGOMERS SPECIFICALLY INDUCE COGNITIVE DEFICITS IN RECOGNITION MEMORY IN MICE
C. Balducci¹, M. Messa², L. Colombo², M. Salmona², G. Forloni^1
1'Mario Negri' Institute of Pharmacological Research, Neuroscience, Milan, Italy, ²'Mario Negri' Institute of Pharmacological Research, Molecular Biochemistry and Pharmacology, Milan, Italy

MICE WITH ALZHEIMER'S DISEASE (APP.V717I) LEARN IN SOCIAL CONTEXT
A. Kiryk¹, R. Filipkowski¹, M. Wawrzyniak¹, V. Lioudyno¹, E. Knapska¹, T. Gorkiewicz¹, M. Balcerzyk¹, F. Van Leuven², L. Kaczmarek^1
1Nencki Institute, Warsaw, Poland, ²Department of Human Genetics, KULeuven, Leuven, Belgium

BEHAVIOURAL STUDIES ON TRANSGENIC APP-ARCSWE-MICE
A. Gumucio Gatica¹, A. Codita², A. Lord¹, B. Winblad², L. Lannfelt¹, A. Mohammed², L.N.G. Nilsson^1
1Molecular Geriatrics, Uppsala University, Department of Public Health & Caring Sciences, Uppsala, Sweden, ²KI-ADRC, Karolinska Institutet, Department of Neurobiology, Caring Sciences & Society, Stockholm, Sweden

NON SPATIAL TEMPORAL MEMORY DEFICITS IN APP/PS1, APP AND PS1 MICE
Y.H. Cho, S. Lagadec, S. Delcasso, X. Toussay, N. Macrez, Y. Jeantet
Bordeaux 1, CNIC, Talence Cedex, France

CLIOQUINOL REDUCES Aβ PLAQUE LOAD AND GLIA REACTION AND IMPROVES COGNITIVE DEFICITS IN AN APP TRANSGENIC MOUSE MODEL
C. Grossi¹, S. Francese², A. Casini³, M.C. Rosi¹, I. Luccarini¹, A. Fiorentini¹, C. Gabbiani³, L. Messori³, G. Moneti², F. Casamenti^1
1University of Florence, Department of Pharmacology, Florence, Italy, ²University of Florence, Mass Spectrometry Center, Florence, Italy, ³University of Florence, Department of Chemistry, Florence, Italy

CURCUMINOIDS AFFECT MULTIPLE GENE EXPRESSION IN AMYLOID INFUSED MODEL OF ALZHEIMER'S DISEASE
T. Ahmed¹, A. Enam², A.-H. Gilani^3
1Drug Discovery and Natural Products Research, Biological and Biomedical Sciences, Aga Khan University, Stadium Road, Karachi, Pakistan, ²Section of Neurosurgery, Department of Surgery, Aga Khan University, Stadium Road, Karachi, Pakistan, ³Drug Discovery and Natural Products Research, Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan

INTRANEURONAL Aβ ACCUMULATION IN THE BASOLATERAL AMYGDALA ENHANCES FEAR AND ANXIETY IN TRANSGENIC MODELS OF ALZHEIMER'S DISEASE
J. España Agustí¹, L. Giménez-Llort², J. Valero Gómez-Lobo¹, A. Rábano³, F.M. La Ferla⁴, C.A. Saura^1
1Institut de Neurociències, Universitat Autònoma de Barcelona, Departament Bioquímica i Biologia Molecular, Cerdanyola del Vallès, Spain, ²Institut de Neurociències, Universitat Autonoma de Barcelona, Departament de Psiquiatria i Medicina Legal, Cerdanyola del Vallès, Spain, ³Unidad de Neuropatología, Fundación Hospital Alcorcón, Alcorcón, Spain, ⁴Institute for Brain Aging and Dementia, Department of Neurobiology and Behavior, Irvine, United States

BRAIN PROTEIN ANALYSIS IN 3XTG-AD MICE BY A 2D-E AND BLUE NATIVE-PAGE COMBINED APPROACH
A. Del Viscovo¹, E. Silvestri¹, M. Moreno¹, C. Corona², D. Ciavardelli², D. De Gregorio¹, F. Goglia¹, S.L. Sensi², L.M.T. Canzoniero^1
1Università del Sannio, Scienze BIologiche ed Ambientali, Benevento, Italy, ²University “G. d'Annunzio”, CeSI, Center for Excellence on Aging, Chieti Scalo, Italy

AMYLOID-β ASSOCIATED INCREASES IN AKT ACTIVATION AND TAU PATHOGENESIS IN THE 3 X TG-AD MODEL: IMPLICATIONS FOR AD
M. Coakley¹, A. Moloney¹, S. Oddo², F. LaFerla², R. Griffin¹, R. O' Connor¹, R. Ravid³, C. O' Neill^1
1University College Cork, Cork, Ireland, ²University of California, Irvine, United States, ³Netherlands Brain Bank, Amsterdam, Netherlands

MEMANTINE LOWERS β-AMYLOID LEVELS: EVIDENCE FROM PRECLINICAL STUDIES
P. Banerjee¹, D.K. Lahiri², H. Tanila³, T. Wisniewski⁴, F. La Ferla^5
1Forest Research Institute, Jersey City, United States, ²Indiana University School of Medicine, Department of Psychiatry, Indianapolis, United States, ³University of Kuopio, Kuopio, Finland, ⁴New York University School of Medicine, New York City, United States, ⁵University of California, Irvine, United States

BEHAVIOURAL CHARACTERISATION OF A TRANSGENIC MOUSE MODEL OVER-EXPRESSING THE NEUROTROPHIN RECEPTOR P75
A. Horvath, M. Mitrovic, B. Hutter-Paier, M. Windisch
JSW CNS Research, Grambach, Austria

PROGRESSION OF BRAIN PATHOLOGY AND BEHAVIOURAL DISTURBANCE IN A MOUSE MODEL (TMHT) OVER-EXPRESSING MUTATED HUMAN TAU
M. Hierzer¹, M. Posch¹, M. Mitrovic¹, K. Groschner², B. Hutter-Paier¹, M. Windisch^1
1JSW CNS Research, Grambach, Austria, ²Uni Graz, Institute of Pharmaceutical Sciences, Graz, Austria

THE PHYSIOLOGICAL LINK BETWEEN METABOLIC RATE DEPRESSION AND TAU PHOSPHORYLATION: WHAT HIBERNATING ANIMALS CAN TEACH US ABOUT ALZHEIMER'S DISEASE
J.T. Stieler¹, T. Bullmann¹, F. Kohl², O. Toien², M.K. Brueckner¹, W. Härtig³, B. Barnes², T. Arendt^1
1Paul Flechsig Institute of Brain Research, Molecular and Cellular Mechanisms of Neurodegeneration, University Leipzig, Germany, ²University of Alaska, Institute of Arctic Biology, Fairbanks, United States, ³Paul Flechsig Institute of Brain Research, Pathophysiology of Neuroglia, University Leipzig, Germany

NEUROPROTECTIVE EFFECTS OF CEREBROLYSIN ON NEUROFIBRILLARY PATHOLOGY IN APP-TRANSGENIC MICE THAT RECEIVED NEURONAL GENE TRANSFER WITH AAV2-TAU
E. Rockenstein¹, K. Ubhi¹, E. Doppler², M. Mante¹, A. Adame¹, C. Patrick¹, A. Paulino¹, H. Moessler², E. Masliah^1
1University of California San Diego, Neurosciences, La Jolla, United States, ²EBEWE Pharma GmbH, Unterach, Austria

THE ROLE OF PIP2 PHOSPHATASE SYNAPTOJANIN 1 IN ALZHEIMER´S DISEASE-LINKED SYNAPTIC AND NEUROBEHAVIORAL DYSFUNCTION
D. Berman, A. Staniszewski, L. McIntire, O. Arancio, G. Di Paolo, T.-W. Kim
Columbia University, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Pathology and Cell Biology, New York, United States

LITHIUM EFFECTS ON ADULT NEUROGENESIS IN THE DENTATE GYRUS OF AN APP TRANSGENIC MOUSE MODEL
A. Fiorentini, M.C. Rosi, I. Luccarini, C. Grossi, F. Casamenti
University of Florence, Department of Pharmacology, Florence, Italy

INHIBITION OF GSK-3β BY LITHIUM IMPROVES AMYLOID PATHOLOGY AND LEARNING AND MEMORY FUNCTIONS IN A HUMAN APP TRANSGENIC MOUSE MODEL
M.C. Rosi, A. Fiorentini, C. Grossi, I. Luccarini, F. Casamenti
University of Florence, Pharmacology, Florence, Italy

OVERACTIVATION OF GLYCOGEN SYNTHASE KINASE-3 DECREASES ACH LEVEL IN NUCLEUS BASALIS OF MEYNERT AND FRONTAL CORTEX
Y. Wang¹, L. Zhao^2
1Xuanwu Hospital, Beijinig, China, ²Netherlands Institute for Neuroscience, Amsterdam, Netherlands

CHANGES OF THE PROLIFERATION MARKER PSA-NCAM DUE TO OVEREXPRESSION OF HAPP, ALPHA-SYNUCLEIN AND TAU441 - COMPARING AD AND PD MODELS
M. Jost¹, D. Havas¹, M. Posch¹, G. Skofitsch², B. Hutter-Paier¹, M. Windisch^1
1JSW CNS Research, Grambach, Austria, ²Uni Graz, Institute for Zoology, Graz, Austria

THE ROLE OF UBB⁺¹ IN A NOVEL TRIPLE TRANSGENIC MOUSE MODEL FOR ALZHEIMER'S DISEASE
M. Lemmens¹, A. Sierksma¹, P. van Tijn², D. Fischer³, L. Zoetebier¹, P. Giesbertz¹, H. Steinbusch¹, F. van Leeuwen¹, C. Schmitz^1
1Maastricht University, School for Mental Health and Neurosciences, Maastricht, Netherlands, ²Hubrecht Institure, Utrecht, Netherlands, ³BioFocus DPI, Leiden, Netherlands

C-REACTIVE PROTEIN INDUCES COGNITIVE DEFICITS AND MOLECULAR BIOLOGICAL ALTERATION IN RAT: IMPLICATIONS FOR ALZHEIMER'S DISEASE
J. Xu
Southern Medical University, Pharmacology, Guangzhou, China

AGENTS THAT ENHANCE CHOLINERGIC NEURAL TRANSMISSION REVERSE COGNITIVE IMPAIRMENT ASSOCIATED WITH BRAIN IRON ACCUMULATION IN RATS
N. Schröder, V. Pieta, R. da Silva, J. Presti-Torres, A. Dornelles, F. Scalco, M. Guimaraes, C. Bonan, M. de Lima
Pontifical Catholic University, Porto Alegre, Brazil

INVOLVEMENT OF PLASTICITY CHANGES IN EARLY-LIFE STRESS EFFECTS ON CHOLINERGIC NEURONS VULNERABILITY AND COGNITION
B. Aisa, F.J. Gil-Bea, B. Marcos, R. Tordera, J. Del Rio, M. Ramirez
University of Navarra, Pharmacology, Pamplona, Spain

BRAIN AREA-SELECTIVE NEUROMODULATORY ACTION OF BETA-AMYLOID
E. Mura¹, S. Preda¹, S. Govoni¹, P. Frattini¹, M. Grilli², M. Marchi^2
1University of Pavia, Department of Experimental and Applied Pharmacology, Pavia, Italy, ²University of Genoa, 2Section of Pharmacology and Toxicology, Department of Experimental Medicine, Genoa, Italy

SEX DOES NOT INFLUENCE THE LOAD OF NEUROFIBRILLARY TANGLES IN THE BRAIN OF TRANSGENIC RAT MODEL OF HUMAN NEURODEGENERATIVE TAUOPATHY
O. Bugos, P. Koson, P. Novak, N. Zilka, M. Novak
Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia

TRUNCATED TAU INDUCES HYPERPHOSPHORYLATION IN TRANSGENIC RAT MODEL OF HUMAN TAUOPATHY
N. Ivanovova, M. Handzusova, E. Kontsekova, M. Novak
Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia

A ROLE FOR THE INSULIN PATHWAY IN AN INDUCIBLE DROSOPHILA MODEL OF ALZHEIMER'S DISEASE
O. Sofola, F. Kerr, L. Partridge
University College London, London, United Kingdom

DIET AND OXIDATIVE STRESS IN THE NEUROPATHOLOGY OF ALZHEIMER'S DISEASE IN DROSOPHILA
F. Kerr¹, H. Cochemé¹, C. Gandy¹, I. Rogers¹, O. Sofola¹, G. Vinti¹, P. Francis², S. Lovestone³, L. Partridge^1
1University College London, Institute of Healthy Ageing, and GEE, London, United Kingdom, ²King's College London, Wolfson Centre for Age-Related Diseases, London, United Kingdom, ³King's College London, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London, United Kingdom

OVEREXPRESSION OF HUMAN AMYLOID PRECURSOR PROTEIN CAUSES NEURODEGENERATION AND LOSS OF SYNAPTIC PROTEINS IN NEURAL CELLS IN TRANSGENIC DROSOPHILA
S. Sarantseva¹, O. Bolshakova¹, S. Timoshenko¹, M. Vitek², A. Schwarzman^3
1Petersburg Nuclear Physics Institute, Gatchina, Russian Federation, ²Duke University Medical Center, Division of Neurology, Durham, United States, ³Institute for Experimental Medicine, St. Petersburg, Russian Federation

EFFECTS OF CHRONIC NICOTINE TREATMENT ON PERFORMANCE IN RADIAL ARM-MAZE TASK IN RATS
L. Hritcu¹, A. Ciobica^2
1Alexandru Ioan Cuza University, Laboratory of Animal Physiology, Iasi, Romania, ²Romanian Academy, Laboratory for Experimental and Applied Physiology, Iasi, Romania

EFFECTS OF CHOLINESTERASE INHIBITOR GALANTAMINE ON SOME MODELS OF IMPAIRED MEMORY
D. Getova, D. Dimitrova
Medical University Plovdiv, Department of Pharmacology, Plovdiv, Bulgaria

NERVE GROWTH FACTOR EYE APPLICATION PROTECTS CHEMICALLY INJURED RAT FOREBRAIN CHOLINERGIC NEURONS IN RATS
L. Aloe¹, M. Fiore², K. Tirassa², A. Lambiase^3
1Istituto di Neurobiologia e Medicina Molecolare, CNR, Rome, Italy, ²Istituto di Neurobiologia e Medicina Molecolare, Rome, Italy, ³Ophthalmology, University of Rome “Campus Bio-Medico', Rome, Italy

AN INTEGRATED RESEARCH PLATFORM FOR NEURODEGENERATIVE DISORDERS' STUDIES: THE BIOPARK OF ARCHAMPS
P. Bulet¹, B. Sudre², J. Demongeot³, P. Marche⁴, N. Bons^5
1TIMC-IMAG, UJF CNRS UMR 5525, Groupement d'Intérêt Public Plateforme BioPark Archamps, Archamps, France, ²Fondation Rhône-Alpes Futur, Plateforme BioPark d'Archamps, Archamps, France, ³TIMC-IMAG, UJF CNRS UMR 5525, Grenoble, France, ⁴INSERM U823, Grenoble, France, ⁵BioPark d'Archamps, Archamps, France

APP PROCESSING IN LIGHT-INDUCED RETINAL DEGENERATION: COMMON MECHANISM OF NEURODEGENERATION WITH ALZHEIMER'S DISEASE
A. Prakasam¹, M. Pappolla¹, B. Rohrer², K. Sambamurti^1
1Medical University of South Carolina, Department of Neurosciences, Charleston, United States, ²Medical University of South Carolina, Ophthalmology, Charleston, United States

EFFECTS OF TOXOPLASMA GONDII INFECTION ON THE PROGRESS OF ALZHEIMER'S DISEASE
B.-K. Jung¹, G.-H. Pyo¹, K.Y. Shin², Y.-H. Suh², J.-Y. Chai¹, E.-H. Shin^3
1Seoul National University College of Medicine, Department of Parasitology and Tropical Medicine, Seoul, Korea, Republic of, ²Seoul National University College of Medicine, Department of Pharmacology, Seoul, Korea, Republic of, ³Seoul National University College of Medicine, Bundang Hospital, Department of Parasitology and Tropical Medicine, Seoul, Korea, Republic of

ENVIRONMENTAL ENRICHMENT AND MENTAL TRAINING IMPROVE COGNITION IN RAT MODEL OF SPORADIC ALZHEIMER'S DISEASE
J. Osmanovic¹, M. Salkovic-Petrisic¹, S. Hoyer², P. Riederer^3
1School of Medicine, University of Zagreb, Department of Pharmacology, Zagreb, Croatia, ²University of Heidelberg, Department of Pathology, Heidelberg, Germany, ³University Department of Psychiatry and Psychotherapy, University of Würzburg, Department of Clinical Neurochemistry, Wuerzburg, Germany

AXONAL TRANSPORT DEFECTS LEAD TO CHANGES IN APP METABOLISM AND TAU CONFORMATION IN HUMAN EMBRYONIC STEM CELL-DERIVED NEURONAL CULTURES
R. Nolan, L. Goldstein
University of California - San Diego, La Jolla, United States

ANTIDEMENTIC MEMANTINE OR SPIN TRAPPING PBN PROTECTS ACHE INHIBITOR-INDUCED OXIDATIVE STRESS AND ENERGY METABOLISM IMPAIRMENT IN BRAIN
R. Gupta¹, D. Milatovic^2
1Murray State University, Toxicology, Hopkinsville, United States, ²Vanderbilt University, Medical Center, Nashville, United States