Poster Presentations

Thursday, March 12 – Friday, March 13 ,2009

Cholesterol and Lipids:

EFFICACY AND SAFETY OF LONG-TERM ATORVASTATIN TREATMENT IN PATIENTS WITH ALZHEIMER'S DISEASE
S. Chumburidze, N. Kipshidze
Nodar Kipshidze National Center of Therapy, Tbilisi, Georgia

ALTERED LIPID COMPOSITION IN LIPID RAFTS FROM ALZHEIMER´S DISEASE BRAIN CORTEX
N. Fabelo¹, V. Martin¹, G. Santpere², B. Puig², I. Ferrer², M. Diaz^3
1Universidad de La Laguna, Departamento de Biología Animal, Facultad de Biología, Spain, ²Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain, ³Universidad de La Laguna, Departamento de Biología Animal, Institute of Biomedical Technologies, Santa Cruz de Tenerife, Spain

CHARACTERIZATION OF LIPID COMPOSITION IN LIPID RAFTS FROM HUMAN BRAIN CORTEX
N. Fabelo¹, V. Martín¹, G. Santpere², B. Puig², I. Ferrer², M. Díaz^1
1Universidad de La Laguna, Departamento de Biología Animal e Instituto de Tecnologías Biomédicas, La Laguna, Spain, ²Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain

CHANGES IN MEMBRANE PHOSPHOLIPIDS COMPOSITION AFFECT ABETA PEPTIDE TOXICITY ON NEURONAL CELL
E. Cazzaniga, A. Bulbarelli, E. Lonati, M. Masserini
University Milano Bicocca, Experimental Medicine, Monza, Italy

BIDIRECTIONAL LINK BETWEEN PLASMALOGEN METABOLISM AND APP PROCESSING
M.O.W. Grimm, J. Kuchenbecker, T. Hartmann
Saarland University, Institute of Neurodegeneration and Neurobiology, Department of Neurology, Homburg, Germany

ALTERATIONS IN SPHINGOLIPID METABOLISM LINKED WITH ALZHEIMER'S DISEASE
M.O.W. Grimm, S. Grösgen, T. Hartmann
Institute of Neurodegeneration and Neurobiology, Department of Neurology, Saarland University, Homburg/Saar, Germany

THE ROLE OF GANGLIOSIDE METABOLISM IN ALZHEIMER`S DISEASE AND APP PROCESSING
M.O.W. Grimm, E.G. Zinser, T. Hartmann
Institute of Neurodegeneration and Neurobiology, Department of Neurology, Saarland University, Homburg/Saar, Germany

MECHANISTIC LINK BETWEEN CHOLESTEROL METABOLISM AND APP PROCESSING
M.O.W. Grimm, V. Burg, T. Hartmann
Saarland University, Institute of Neurodegeneration and Neurobiology, Department of Neurology, Homburg/Saar, Germany

PLANT STEROLS IN THE BRAIN, GOOD OR BAD?
T. Vanmierlo¹, K. Rutten², A. Blokland², J. Prickaerts², F. Kuipers³, K. Blennow⁴, H. Steinbusch², M. Mulder⁵, D. Lütjohann^1
1University of Bonn, Institute of Clinical Chemistry and Pharmacology, Bonn, Germany, ²Maastricht University, School for Mental Health and Neuroscience, Maastricht, Netherlands, ³University Medical Center Groningen, Dept. of Pediatrics, Groningen, Netherlands, ⁴University of Göteborg, Dept. of Neuroscience and Physiology, Götenborg, Sweden, ⁵Erasmus Medical Center Rotterdam, Dept. of Internal Medicine, Dept. of Pharmacology, Rotterdam, Netherlands

SORLA/LR11 IN GLIA: RELATION TO THE MEMBRANE RAFT PROTEIN CAVEOLIN-1
I. Salgado¹, N. Martinez¹, M. Serrano¹, J. Garcia¹, H. Maldonado², C. Baez³, J. Lasalde³, W. Silva^1
1University of Puerto Rico, Physiology/School of Medicine, San Juan, Puerto Rico, ²Universidad Central del Caribe, Pharmacology/School of Medicine, Bayamon, Puerto Rico, ³University of Puerto Rico, Biology, Rio Piedras, Puerto Rico

EFFECTS OF CHOLESTEROL AND DHA DIETS ON COGNITION, β-AMYLOID DEPOSITION AND SYNAPTIC DENSITY IN 8- AND 15-MONTH-OLD APP/PS1 ALZHEIMER MICE
D. Jansen¹, C.R. Hooijmans², M.P.C. Mutsaers¹, A. Hafkemeijer¹, A.L. Janssen¹, A.M.C.M. Doedée², P.J. Dederen¹, A. Kuipers³, L. Broersen³, A.J. Kiliaan^1
1Radboud University Nijmegen Medical Centre, Dept. Anatomy & Dept. Cognitive Neuroscience, Donders Centre for Neuroscience, Nijmegen, Netherlands, ²Radboud University Nijmegen Medical Centre, Dept. Anatomy, Nijmegen, Netherlands, ³Danone Research, Wageningen, Netherlands

SIMVASTATIN PRESERVES COGNITIVE FUNCTION AND ENHANCES SYNAPTIC PLASTICITY IN A MOUSE MODEL OF ALZHEIMER'S DISEASE
L. Li¹, D. Cao¹, N. Chowdhury¹, R. Mans¹, T. Lewis¹, H. Lu¹, L. Mcmahon^2
1University of Alabama at Birmingham, Medicine, Birmingham, United States, ²University of Alabama at Birmingham, Physiology & Biophysics, Birmingham, United States

THE POLYUNSATURATED FATTY ACIDS DOCOSAHEXAENOIC ACID REDUCES β-AMYLOID INDUCED PROINFLAMMATORY CYTOKINES EXPRESSION WHILE MAINTAINS THE CLEARANCE CAPABILITY OF β-AMYLOID IN BMDMS
S. Liu¹, Y. Liu¹, W. Hao¹, B. Penke², T. Hartmann¹, K. Fassbender^1
1Saarland University, Neurology, Homburg, Germany, ²Hungarian Academy of Sciences, University of Szeged, Medicinal Chemistry and Protein Research Group, Szeged, Hungary

GW3965 REQUIRES ABCA1 FOR BENEFICIAL BIOCHEMICAL AND COGNITIVE OUTCOMES IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER'S DISEASE
J. Donkin, P. Parkinson, V. Hirsch-Reinshagen, S. Stukas, A. Wilkinson, J. Fan, J. Chan, C. Wellington
University of British Columbia, Pathology and Laboratory Medicine, Vancouver, Canada

THE CHANGES IN THE LIPID PHASE OF BRAIN CELL MEMBRANES IN MICE BEARING EXPERIMENTAL ALZHEIMER'S-LIKE DISEASE
E. Burlakova, E. Molochkina, N. Gerasimov, L. Fatkullina, A. Goloschapov, I. Goncharova
Institute of Biochemical Physics RAS, Biochemical Kinetics, Moscow, Russian Federation

THE EFFECT OF A KETOGENIC DIET ON MOTOR PERFORMANCE AND AMYLOID β ACCUMULATION IN APP TRANSGENIC MICE
D. Niedowicz¹, T. Beckett¹, A. Weidner¹, C. Studzinski², M.P. Murphy^1
1University of Kentucky, Center on Aging/Department of Molecular and Cellular Biochemistry, Lexington, United States, ²University of Toronto, Department of Pharmacology, Toronto, Canada

DIETARY RESTRICTION MODULATES AGE RELATED CHANGES OF CHOLESTEROL CONTENT AND CYP46 EXPRESSION IN THE RAT HIPPOCAMPUS
K. Smiljanic¹, V. Maksimovic², A. Mladenovic Djordjevic¹, M. Perovic¹, V. Tesic¹, S. Ruzdijic¹, S. Kanazir^1
1Institute for Biological Research, Belgrade, Serbia, ²Institute for Multidisciplinary Research, Belgrade, Serbia

THE ROLE OF PHOSPHOLIPID TRANSFER PROTEIN (PLTP) AT THE BLOOD-BRAIN BARRIER (BBB) AND IN THE BRAIN
T. Becker¹, C. Schweinzer¹, K. Hasslitzer¹, J. Stefulj¹, W. Sattler², U. Panzenböck^1
1Institute of Pathophysiology and Immunology, Medical University Graz, Graz, Austria, ²Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria

BIOACTIVE LIPIDS AND ATP-BINDING CASSETTE TRANSPORTERS AS MODULATORS OF EXTRACELLULAR AMYLOID-BETA CONCENTRATION
W.S. Kim¹, S.L. Chan¹, A.F. Hill², G.J. Guillemin³, B. Garner^1
1Prince of Wales Medical Research Institute, Cellular Lipidology Group, Sydney, Australia, ²University of Melbourne, Department of Pathology, Melbourne, Australia, ³St Vincent's Hospital, Centre for Immunology, Sydney, Australia

POLYUNSATURATED FATTY ACID ENRICHMENT SPECIFICALLY PREVENTS AMYLOID-β TOXICITY IN HT22 AND SN56 NEURONAL-DERIVED CELL LINES
V. Martín¹, N. Fabelo¹, R. Marín², M. Díaz^1
1Universidad de La Laguna, Departamento de Biología Animal e Instituto de Tecnologías Biomédicas, La Laguna, Spain, ²Universidad de La Laguna, Departamento de Fisiología e Instituto de Tecnologías Biomédicas, La Laguna, Spain

CHOLESTEROL MODULATES AMYLOID BETA PEPTIDE_1-42 CHANNEL FORMATION IN PLANAR LIPID MEMBRANES
D. Meleleo, G. Notarachille, E. Gallucci, S. Micelli
University of Bari, Farmaco-Biologico, Bari, Italy

EXPRESSION OF CHOLESTEROL HOMEOSTASIS GENES IN THE RAT BRAIN IS AFFECTED BY AGE AND DIETARY RESTRICTION
A. Mladenovic Djordjevic, M. Perovic, N. Tanic, K. Smiljanic, V. Tesic, S. Ruzdijic, S. Kanazir
Institute for Biological Research, Belgrade, Serbia

CORRELATION BETWEEN VITAMIN E AND STATIN LEVELS AND THE DEVELOPMENT OF ALZHEIMERS DISEASE IN A MOUSE
H. Omidi¹, P. Pasbakhsh², N. Omidi^3
1Azad University of Tehran/Research Center, Commercial Managment, Tehran, Iran, Islamic Republic of, ²University of Tehran/Medical School, Anatomy, Tehran, Iran, Islamic Republic of, ³University of Tehran/Medical School, Tehran, Iran, Islamic Republic of

MANIPULATION OF VASCULAR RISK FACTORS IN ALZHEIMER´S MOUSE MODELS
A. McCampbell, K. Wessner, S.-J. Na, J. Majercak, W.J. Ray, M. Savage
Merck & Co., Neuroscience, West Point, United States