Poster Presentations

Friday, March 14 – Saturday, March 15, 2009

Neurodevelopment and Neurodegeneration:

MITOCHONDRIAL DEPENDENCY FOR ER STRESS-MEDIATED CELL DEATH INDUCED BY THE AMYLOID-BETA PEPTIDE
E. Ferreiro, R. Costa, S. Cardoso, C. Resende de Oliveira, C. Pereira
Center for Neuroscience and Cell Biology, Coimbra, Portugal

EXPRESSION OF PROBDNF AND P75 IN THE AGING RAT HIPPOCAMPUS
M. Perovic, V. Tesic, A. Mladenovic-Djordjevic, S. Kanazir
Institute for Biological Research Sinisa Stankovic, Belgrade, Serbia

DEVELOPMENT NEUROTOXICOLOGICAL RISK ASSESSMENT OF THE MANGANESE (DNTRAM): ROLE OF CHEMICAL SPECIATION AND CELL TYPE
R. Bonne Hernandez¹, M. Farina², B. Pannia Espósito¹, C. Suñol^2
1University of Sao Paulo/ Chemistry Institute, Fundamental Chemistry, Sao Paulo, Brazil, ²Instituto de Investigaciones Biomedicas de Barcelona, Barcelona, Spain

ACTIVATION OF THE UNFOLDED PROTEIN RESPONSE FOLLOWING PROTEASOME INHIBITION IS AFFECTED IN AGED RAT HIPPOCAMPUS
M.P. Gavilan¹, E. Gavilan², C. Pintado², R.M. Rios¹, J. Vitorica², A. Castaño², D. Ruano^2
1Centro Andaluz de Biología Molecular y Medicina Regenerativa, Señalizacion Celular, Sevilla, Spain, ²Facultad de Farmacia- Universidad de Sevilla, Bioquimica, Bromatologia, Toxicologia y Medicina Legal, Sevilla, Spain

GSKIP, A NEGATIVE REGULATOR OF GSK3β ACTIVITY, MEDIATES N-CADHERIN-BOUND B-CATENIN POOL IN RETINOID ACID-INDUCED DIFFERENTIATION OF SH-SY5Y CELLS
Y.-R. Hong
Faculty of Medience, Department of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China

AMYLOID ß PRODUCTION IS IMPORTANT FOR CELL VIABILITY AND NEURITE OUTGROWTH
R. Sayer¹, T.L. Kerrigan¹, C. Peers², H.A. Pearson^1
1University of Leeds, Institute of Membrane and Systems Biology, Leeds, United Kingdom, ²University of Leeds, Division of Cardiovascular and Neuronal Remodelling, Leeds, United Kingdom

DIFFERENT EXPRESSION OF SMAD ISOFORMS DURING BRAIN DEVELOPMENT AND AGING
U. Ueberham¹, P. Lange¹, E. Ueberham², M. Brückner¹, M. Hartlage-Rübsamen¹, T. Pannicke³, E. Frick¹, T. Arendt^1
1Paul Flechsig Institute of Brain Research, University Leipzig, Department for Molecular and Cellular Mechanisms of Neurodegeneration, Leipzig, Germany, ²Institute of Biochemistry, University Leipzig, Leipzig, Germany, ³Paul Flechsig Institute of Brain Research, University Leipzig, Department for Pathophysiology of Neuroglia, Leipzig, Germany

EFFECTS OF AGEING ON ADULT HIPPOCAMPAL NEUROGENESIS
N. Morgenstern, G. Lombardi, A. Schinder
Neuronal Plasticity Lab, Fundacion Instituto Leloir, Buenos Aires, Argentina

MELATONIN ATTENUATES INDUCTION OF BAX- AND CASPASE-DEPENDENT DEATH SIGNALING IN METHAMPHETAMINE-TREATED HUMAN NEUROBLASTOMA SH-SY5Y CULTURED CELLS
B. Chetsawang¹, W. Wisessmith¹, P. Govitrapong^2
1Neuro-Behavioural Biology Center, Institute of Science and Technology for Research and Development, Mahidol University, Salaya, Nakhonpathom, Thailand, ²Neuro-Behavioural Biology Center, Institute of Science and Technology for Research and Development, Salaya Nakhonpathom and Center for Neuroscience and Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand

SCREENING OF POTENTIAL NEURONAL CELL DEATH MODULATORS IN DYRK1A-OVEREXPRESSING HIPPOCAMPAL CELLS
Y. Oh, J. Park, K.C. Chung
Yonsei University, Department of Biology, Seoul, Korea, Republic of

CYCLIN-DEPENDENT KINASE-5 (CDK5) PHOSPHORYLATES CDH1 LEADING TO CYCLIN B1 ACCUMULATION DURING EXCITOTOXIC NEURODEGENERATION
C. Maestre¹, J.C. Gomez-Sanchez², J.P. Bolaños³, A. Almeida^1
1Hospital Universitario de Salamanca, Unidad de Investigacion, Salamanca, Spain, ²Hospital Universitario de Salamanca, Servicio de Neurologia, Salamanca, Spain, ³Universidad de Salamanca, Bioquimica y Biologia Molecular, Salamanca, Spain

LITHIUM REDUCES NEURODEGENERATION MARKERS IN EXPERIMENTAL MODELS OF AGEING
M. Tajes, J. Gutierrez-Cuesta, A. Camins, M. Pallas
Universtiy of Barcelona, Faculty of Pharmacy, Barcelona, Spain

OVEREXPRESSION OF HUMAN PUROMYCIN-SENSITIVE AMINOPEPTIDASE (PSA) ATTENUATES ACCUMULATION OF PHOSPHORYLATED TAU
L. Kudo¹, N. Vi², K. Lau¹, L. Parfenova¹, M. Hui³, M. Gray⁴, X.W. Yang⁴, M. Wiedau-Pazos¹, K.-S. Hui³, S. Karsten^1
1David Geffen School of Medicine at UCLA, Neurology, Los Angeles, United States, ²LABioMed at Harbor-UCLA, Neurology, Torrance, United States, ³Nathan S. Kline Institute for Psychiatric Research, Orangeburg, United States, ⁴UCLA, Psychiatry and Biobehavioral Sciences, Los Angeles, United States

INVOLVEMENT OF STANNIOCALCIN-1 IN NEURODEGENERATION
L.C. Andersson, P. Lankila, O. Saavalainen, J. Westberg
University of Helsinki, Pathology, Helsinki, Finland

DEVELOPMENTAL CHANGES IN THE CALCIUM CHANNEL AND D1-LIKE RECEPTORS INVOLVED IN THE GLUTAMATERGIC TRANSMISSION ONTO RAT BASAL FOREBRAIN CHOLINERGIC NEURONS
T. Momiyama
Jikei University School of Medicine, Department of Pharmacology, Tokyo, Japan

NEUROPATHOLOGICAL FEATURES OF DOWN SYNDROME SHOWN IN DYRK1A-OVEREXPRESSING IMMORTALIZED HIPPOCAMPAL NEURONS
J. Park, Y. Oh, K.C. Chung
Yonsei University, Department of Biology, Seoul, Korea, Republic of

PRENATAL EXPOSURE TO ETHANOL BUT NOT RED WINE CAUSES AGE-RELATED DEFICITS IN RODENTS
M. Fiore¹, L. Aloe², R. Mancinelli³, G. Laviola⁴, M. Ceccanti^5
1Istituto di Neurobiologia e Medicina Molecolare, CNR, Rome, Italy, ²Istituto di Neurobiologia e Medicina Molecolare, Rome, Italy, ³Dipartimento Ambiente e connessa Prevenzione Primaria, Istituto Superiore di Sanità, Rome, Italy, ⁴Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, Rome, Italy, ⁵Centro Riferimento Alcologico Regione Lazio, Universita' di Roma ''La Sapienza'', Rome, Israel

ULTRASTRUCTURAL ANALYSIS OF SYNAPTIC LOSS IN MURINE PRION DISEASE: EVIDENCE FOR PHAGOCYTOSIS BY PYRAMIDAL CELL DENDRITIC SPINES
Z. Siskova, V. O'Connor, V.H. Perry
School of Biological Sciences, Southampton, United Kingdom

POTENTIAL MECHANISM OF CELL DEATH IN THE DEVELOPING RAT BRAIN INDUCED BY PROPOFOL ANESTHESIA
V. Pesic¹, D. Milanovic¹, N. Tanic¹, J. Popic¹, S. Kanazir¹, V. Jevtovic-Todorovic², S. Ruzdijic^1
1Institute for Biological Research, Belgrade, Serbia, ²University of Virginia Health System, Charlottesville, United States

OESTROGEN RECEPTOR ALPHA IS INTEGRATED INTO CAVEOLAE OF HUMAN NEURONS ASSOCIATED WITH A VOLTAGE-DEPENDENT ANION CHANNEL (VDAC)
R. Marin¹, M. González², C.M. Ramirez¹, G. Santpere³, B. Puig³, I. Ferrer³, G. Meyer², R. Alonso¹, M. Díaz González^4
1La Laguna University, Physiology, La Laguna, Spain, ²La Laguna University, Anatomy, La Laguna, Spain, ³IDIBELL-Hospital, Bellvitge University, Institute of Neuropathology, Hospitalet de Llobregat, Spain, ⁴La Laguna University, Animal Biology, La Laguna, Spain

8-HYDROXY QUINOLINE EFFECTS ON NEURONAL PLASTICITY
P. Adlard, D. Finkelstein, J. Parncutt, M. Nurjono, G. Filiz, R. Cherny, A. Bush
The Mental Health Research Institute, Parkville, Australia

N-METHYL-D-ASPARTATE RECEPTOR-BASED PATHOLOGICALLY ACTIVATED NEUROPROTECTION OF BIS(PROPYL)-COGNITIN
W. Li, J. Luo, M. Mak, Y. Han
The Hong Kong PolyU, Dept. Of ABCT, Kowloon, Hong Kong

TRAFFICKING, PROCESSING AND SIGNALING OF APOER2 IN NIEMANN-PICK TYPE C DISEASE MODELS
M.L. Benitez¹, F. Bronfman², M.P. Marzolo^1
1Pontificia Universidad Catolica de Chile, Centro Fondap de Regulacion Celular y Patologia, Dept. Biologia Celular y Molecular, Santiago, Chile, ²Pontificia Universidad Catolica de Chile, Centro Fondap de Regulacion Celular y Patologia, Dept. Ciencias Fisiologicas, Santiago, Chile

EFFECT OF PROTEASOME INHIBITION IN GOLGI APPARATUS AND CENTROSOME STRUCTURE - RELEVANCE IN PARKINSON´S DISEASE PATHOPHYSIOLOGY
F. Diaz-Corrales¹, M.P. Gavilan¹, D. Ruano², R.M. Rios^1
1Centro Andaluz de Biología Molecular y Medicina Regenerativa, Señalizacion Celular, Sevilla, Spain, ²Facultad de Farmacia- Universidad de Sevilla, Bioquimica, Bromatologia, Toxicologia y Medicina Legal, Sevilla, Spain

TEMPORAL AND REGIONAL PROFIL OF ALPHA-II-SPECTRIN BEAKDOWN PRODUCTS AFTER REPEATED PROPOFOL EXPOSURE IN IMMATURE RAT BRAINS
D. Milanovic¹, V. Pesic¹, J. Popic¹, N. Tanic¹, N. Loncarevic¹, V. Jevtovic-Todorovic², S. Kanazir³, S. Ruzdijic^3
1Institute for Biological Reserarch, Belgrade, Serbia, ²Department of Anesthesiology, University of Virginia Health System, Charlottesville, United States, ³Institute for Biological Research, Belgrade, Serbia

ROLE OF N-METHYL-D-ASPARTATE RECEPTORS IN ENDOPLASMIC RETICULUM STRESS INDUCED BY AMYLOID-BETA OLIGOMERS
R.O. Costa¹, P.N. Lacor², I.L. Ferreira¹, A.C. Rego¹, W.L. Klein², C. Pereira^1
1Center for Neuroscience and Cell Biology, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal, ²Northwestern University, NBP, Evanston, United States

CROSSING OF NEURONAL PATHWAYS
S. Banihani
Jordan University of Science and Technology, Anatomy, Irbid, Jordan

IN VITRO ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF MAHANIMBINE IN MURRAYA KOENIGII
N. Satheesh Kumar, P.K. Mukherjee
Jadavpur University, School of Natural Product Studies, Department of Pharmaceutical Technology, Kolkata, India

­DOPAMINERGIC AND SEROTONINERGIC STRIATAL SYSTEMS ARE SIMILARLY ALTERED IN PARKINSON'S DISEASE AND HUNTINGTON'S CHOREA
C. Bedard¹, M.-J. Wallman¹, M. Parent², A. Parent^1
1Laval University, Anatomy and Physiology, Quebec, Canada, ²Montreal University, Montreal, Canada

BETA-AMYLOID INDUCES AN ENHANCEMENT OF PARP ACTIVITY IN A CELLULAR MODEL OF NEURODEGENERATION
L. Mosca¹, I. De Zottis¹, A. Sansone², C. Giordano³, R. Chiaraluce¹, I. Tempera⁴, A. Mai², M. d'Erme^5
1'Sapienza' University, Department of Biochemical Sciences, Roma, Italy, ²'Sapienza' University, Department of Pharmaceutical Studies, Roma, Italy, ³CNR, Institute of Biomolecular Chemistry, Roma, Italy, ⁴Wistar Institute, Philadelphia, United States, ⁵Istituto Pasteur - Fondazione Cenci Bolognetti, Roma, Italy