Poster Presentations

Friday, March 14 – Saturday, March 15, 2009

Biomarkers and Diagnostics in Prevention and Treatment:

SERUM PROGRANULIN IS A NONINVASIVE BIOMARKER FOR FRONTOTEMPORAL LOBAR DEGENERATION
K. Sleegers¹, N. Brouwers¹, P. Van Damme², S. Engelborghs³, I. Gijselinck¹, J. van der Zee¹, K. Peeters¹, M. Mattheijssens¹, M. Cruts¹, R. Vandenberghe⁴, P. De Deyn³, W. Robberecht², C. Van Broeckhoven^1
1University of Antwerp, VIB - Department of Molecular Genetics, Antwerpen, Belgium, ²University Hospital Gasthuisberg, University of Leuven, VIB - Laboratory for Neurobiology and Vesalius Research Center and Department of Neurology, Leuven, Belgium, ³ZNA Middelheim, Memory Clinic and Division of Neurology, Antwerpen, Belgium, ⁴University Hospital Gasthuisberg, University of Leuven, Department of Neurology, Leuven, Belgium

VISUAL EVOKED OSCILLATORY RESPONSES OF ALZHEIMER PATIENTS
G.G. Yener¹, B. Güntekin², E. Tülay², E. Başar^2
1Dokuz Eylul University, Brain Dynamics and Multidisciplinary Research Center, Departments of Neurology and Neurosciences, Izmir, Turkey, ²Brain Dynamics, Cognition and Complex Systems Research Unit, Istanbul Kültür University, Istanbul, Turkey

LONGITUDINAL CSF BIOMARKER LEVELS AND COGNITION IN HEALTHY ELDERLY
E. Stomrud¹, O. Hansson¹, H. Zetterberg², K. Blennow², L. Minthon¹, E. Londos^1
1Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden, ²Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, Göteborg, Sweden

NEUROIMMUNE MARKERS OF NEURODEGENERATION IN ALZHEIMER'S AND PARKINSON'S DISEASE MEASURED BY ELISA
L. Morozova-Roche
Umea University, Umea, Sweden

IMPROVING ANALYTICAL PERFORMANCE OF MULTIPLEX TAU/PHOSPHO-TAU ASSAY IN PLASMA USING MAGPLEX™ MICROSPHERES
C. Catry¹, H. Decraemer¹, P. Grognet¹, D. Jacobs¹, J. Winderinckx², F. Van Leuven², E. Vanmechelen^1
1Innogenetics NV, R&D, Gent-Zwijnaarde, Belgium, ²K.U.Leuven, Leuven, Belgium

FIRST STEPS IN DEVELOPMENT OF MAGNETICALLY ACTIVE MINIATURIZED ANALYTICAL SYSTEM FOR DIAGNOSIS OF ALZHEIMER DISEASE
B. Jankovicova¹, Z. Zverinova¹, R. Mohamadi², M. Slovakova¹, A. Charvatova¹, W. Faigle³, J.-L. Viovy², Z. Bilkova^1
1University of Pardubice, Department of Biological and Biochemical Sciences, Pardubice, Czech Republic, ²Institut Curie, Laboratoire Physicochimie, Paris, France, ³Institut Curie, Laboratoire de Spectrométrie de Massel Protéomique, Paris, France

BIOCHEMICAL CHARACTERISATION OF A TRANSGENIC MOUSE (JACKSON) MODEL OF ALZHEIMERS FED A PRO-OXIDANT DIET (I)
M. Broadstock¹, E. Jones¹, R. Lewinsky², C. Mitchelmore², P. Francis^1
1King's College London, Wolfson Centre for Age-Related Diseases, London, United Kingdom, ²Roskilde University, Roskilde, Denmark

BIOCHEMICAL CHARACTERISATION OF A TRANSGENIC MOUSE (TASTPM) MODEL OF ALZHEIMERS FED A PRO-OXIDANT DIET (II)
M. Broadstock¹, R. Lewinsky², C. Mitchelmore², P. Francis^1
1King's College London, Wolfson Centre for Age-Related Diseases, London, United Kingdom, ²Roskilde University, Roskilde, Denmark

AQT - TESTS YOUR COGNITIVE SPEED! A REVIEW OF A VALIDATED SCREENING TOOL FOR DEMENTIA WITH MANY POTENTIAL APPLICATIONS
S. Palmqvist, L. Minthon, O. Hansson, E. Londos
Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Malmö, Sweden

AN ALTERNATIVE SCREENING AND OUTCOME MEASURE FOR AD AND MCI CLINICAL TRIALS: THE COMPUTERIZED NEUROPSYCHOLOGICAL TEST BATTERY (CNTB)
A. Veroff¹, L. Kingery², J. Chandler³, Y. Peng⁴, R. Vogt⁵, L.H. Mozley⁶, M. Marsico³, C. de Jaeger^7
1i3 Research, Clinical Training and Assessments, Bethesda, United States, ²i3 Research, Clinical Training and Assessments, Geneva, United States, ³Merck and Co, Inc, Epidemiology, Upper Gwynedd, United States, ⁴Merck and Co, Inc, Biostatistics, Upper Gwynedd, United States, ⁵Merck and Co, Inc, Experimental Medicine, Upper Gwynedd, United States, ⁶Merck and Co, Inc, Clinical Neuroscience, Upper Gwynedd, United States, ⁷Oxford University, Oxford, United Kingdom

SAMPLE SIZE ESTIMATES AND POWER OF NEUROPSYCHOLOGICAL OUTCOME MEASURES: A COMPARISON OF THE ADAS-COG, NTB, AND CNTB
L. Kingery¹, A. Veroff^2
1i3 Research, Clinical Training and Assessments, Geneva, United States, ²i3 Research, Clinical Training and Assessments, Bethesda, United States

DEVELOPMENT AND VALIDATION OF NEW MEASURES OF LONG TERM MEMORY CONSOLIDATION
J. Chandler¹, Y. Peng², R. Vogt³, L.H. Mozley⁴, M. Marsico¹, A. Veroff⁵, C. de Jaeger^6
1Merck and Co, Inc, Epidemiology, Upper Gwynedd, United States, ²Merck and Co, Inc, Biostatistics, Upper Gwynedd, United States, ³Merck and Co, Inc, Experimental Medicine, Upper Gwynedd, United States, ⁴Merck and Co, Inc, Clinical Neuroscience, Upper Gwynedd, United States, ⁵i3 Research, Clinical Training and Assessments, Bethesda, United States, ⁶Oxford University, Oxford, United Kingdom

THE COMPARATIVE EVALUATION OF SERUM HOMOCYSTEIN LEVEL IN THE PATIENT WITH PARKINSON DISEASE (PD) AND HEALTHY PEOPLE
M. Sedighi, A. Masoud
KAUMS, Kashan, Iran, Islamic Republic of

TIME PARAMETERS OF SACCADIC EYE MOVEMENTS AS ADDITIONAL MARKERS OF DIFFERENTIAL DIAGNOSTICS OF EXTRAPYRAMIDAL DISORDERS
R. Bogdanov¹, P. Ratmanova², A. Kunitsyna¹, D. Napalkov², L. Turbina¹, S. Kotov^1
1Moscow Regional Scientific Research Clinical Institute n.a. M.F. Vladimirsky, Department of Neurology, Moscow, Russian Federation, ²Moscow State University, Moscow, Russian Federation

NEUROCHEMICAL DEMENTIA DIAGNOSTICS: STATE OF THE ART AND A SIMPLE ALGORITHM FOR INTERPRETATION OF CSF BIOMARKERS
R. Zimmermann¹, J. Kornhuber¹, J. Wiltfang², P. Lewczuk^1
1Universitätsklinikum Erlangen, Department of Psychiatry and Psychotherapy, Erlangen, Germany, ²Rheinische Kliniken Essen, University of Duisburg-Essen, Department of Psychiatry and Psychotherapy, Essen, Germany

DISCOVERY AND VALIDATION OF MARKERS FOR ALZHEIMER´S DISEASE USING ISOBARIC PROTEIN TAGGING
A. Güntert¹, D. O'Brien¹, J. Campbell², H. Byers², A. Thompson³, M. Ward², S. Lovestone^1
1Kings College London, Old Age Psychiatry, London, United Kingdom, ²Proteome Sciences PLC, London, United Kingdom, ³Kings College London, Neuroscience, London, United Kingdom

ASYMMETRIC DIMETHYLARGININE IN THE PLASMA OF PATIENTS WITH ALZHEIMER'S AND PARKINSON'S DISEASES
J. Dorszewska¹, J. Florczak², W. Kozubski^2
1Poznan University of Medical Sciences, Laboratory of Neurobiology, Department of Neurology, Poznan, Poland, ²Poznan University of Medical Sciences, Chair and Department of Neurology, Poznan, Poland

CORRELATING PLASMA TDP-43 LEVELS WITH POST-MORTEM IMMUNOHISTOPATHOLOGY IN PATIENTS WITH ALZHEIMER'S DISEASE AND FRONTOTEMPORAL LOBAR DEGENERATION
P. Foulds¹, D. Allsop¹, D. Mann², Y. Davidson², E. Bigio^3
1Lancaster University, Biology, Lancaster, United Kingdom, ²Manchester University, Manchester, United Kingdom, ³NADC, Division of Neuropathology, Chicago, United States

MODULATORY EFFECTS OF CEREBROLYSIN ON TNF-ALPHA AND IGF-I IN ALZHEIMER'S DISEASE
A. Alvarez¹, C. Sampedro¹, L. Corzo¹, R. Cacabelos¹, M. Aleixandre², M. Vargas², C. Linares³, E. Granizo³, E. Doppler⁴, P. Novak⁴, H. Moessler^4
1EuroEspes Biomedical Research Centre, A Coruña, Spain, ²Geroclinic, Granada, Spain, ³Memory Clinic, Malaga, Spain, ⁴Ebewe Pharma, Unterach, Austria

SMELL IDENTIFICATION DEFICIT IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT PREDICTS ALZHEIMER´S DISEASE
H. Magerova, M. Vyhnalek, A. Varjassyova, J. Laczo, M. Bojar, J. Hort
Charles University, 2nd Medical School / Motol Hospital, Dept. of Neurology, Memory Disorders Clinic, Prague, Czech Republic

A BLOOD BASED GENE EXPRESSION TEST FOR THE EARLY DETECTION OF ALZHEIMER'S DISEASE
H.-M. Andersen, B. Booij, K. Bårdsen, G. Grave, M. Kauczynska, L. Kristiansen, T. Lindahl, A. Lönneborg, P. Rye, P. Sharma
DiaGenic ASA, Oslo, Norway

TDP-43: A PUTATIVE BIOMARKER FOR NEURODEGENERATIVE DISEASES
H.B. Kuiperij¹, J.H. Schelhaas¹, W.J.A. van Geel², M.M. Verbeek^1
1Radboud University Nijmegen Medical Centre, Dept. of Neurology and Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands, ²Radboud University Nijmegen Medical Centre, Laboratory of Pediatrics and Neurology, Nijmegen, Netherlands

CALCIUM HOMEOSTASIS IS DYSREGULATED IN PARKINSONIAN PATIENTS WITH L-DOPA INDUCED DYSKINESIAS
E. Bazzini¹, F. Blandini¹, F. Marino², F. Saporiti², M. Armentero¹, C. Pacchetti¹, R. Zangaglia¹, E. Martignoni³, S. Lecchini², G. Nappi⁴, M. Cosentino^2
1Interdepartmental Research Center for Parkinson's Disease (CRIMP), IRCCS Neurological Institute C. Mondino, Pavia, Italy, ²University of Insubria, Varese, Italy, ³Scientific Institute of Veruno, Italy/ University of Insubria, Varese, Italy, ⁴University of Rome “La Sapienza”, Rome, Italy /Interdepartmental Research Center for Parkinson's Disease (CRIMP), IRCCS Neurological Institute C. Mondino, Pavia, Italy

EARLY DETECTION OF COGNITIVE DECLINE USING UNOBTRUSIVE AND CONTINUOUS MONITORING
M. Pavel¹, H. Jimison^2
1Oregon Health & Science University, Biomedical Engineering, Prtland, United States, ²Oregon Health & Science University, Medical Informatics and Clinical Epidemiology, Portland, United States

THE SAMPLE REGISTRY: SERIAL ALZHEIMER'S AND MCI PROSPECTIVE LONGITUDINAL EVALUATION
J. Flax
PrecisionMed Inc., Solana Beach, United States

IMPROVED DISCRIMINATION OF ALZHEIMER'S DISEASE (AD) FROM NON-AD DEMENTIAS USING CSF P-TAU_181P
N. Le Bastard¹, K. Koopman², J.-J. Martin¹, G. Nagels², P.P. De Deyn¹, S. Engelborghs^1
1University of Antwerp, Institute Born-Bunge, Antwerp, Belgium, ²Middelheim General Hospital, Department of Neurology and Memory Clinic, Antwerp, Belgium

COMPARISON OF CEREBRAL GLUCOSE METABOLISM BETWEEN ALZHEIMER'S DISEASE AND DEMENTIA WITH LEWY BODIES
T. Feng, X. Zhao, L. Lu
Beijing Tiantan Hospital, Capital Medical University, Department of Neurology, Beijing, China

SINGLE PARTICLE DETECTION AS TOOL FOR DIAGNOSIS AND MONITORING OF DISEASES ASSOCIATED WITH PROTEIN AGGREGATION
O. Bannach¹, F. Henke¹, S. Hübinger¹, S.A. Funke², L. Wang², D. Willbold³, E. Birkmann^3
1Heinrich-Heine-Universitaet Duesseldorf, Duesseldorf, Germany, ²Forschungszentrum Juelich, Juelich, Germany, ³Forschungszentrum Juelich & Heinrich-Heine-Universitaet Duesseldorf, Duesseldorf, Germany

QUANTITATIVE ANALYSIS OF THE FINGER-TAPPING CONTACT FORCE IN PARKINSON'S DISEASE BY ACCELEROMETER
M. Yokoe¹, R. Okuno², K. Akazawa³, S. Sakoda^1
1Osaka University Graduate School of Medicine, Neurology, Suita, Japan, ²Setsunan University, Electrical and Electronics Engineering, Faculty of Engineering, Neyagawa, Japan, ³Osaka Institute of Technology, Biomedical Engineering, Osaka, Japan

ROUTINE NEUROPHYSIOLOGIC TREMOR ANALYSIS AS A DIAGNOSTIC TOOL FOR PARKINSONIAN TREMOR
N. Kovacs¹, I. Balas², J. Janszky¹, C. Llumiguano², K. Horvath¹, F. Nagy^2
1University of Pecs, Department of Neurology, Pecs, Hungary, ²University of Pecs, Department of Neurosurgery, Pecs, Hungary