Poster Presentations

Friday, March 14 – Saturday, March 15, 2009

Inflammation:

PRESENILIN 2 MODULATES MICROGLIA ACTIVATION
S. Jayadev, A. Case, L. Seaburg, H. Nguyen, G. Garden
University of Washington Medical Center, Neurology, Seattle, United States

IMMUNE STUDIES IN PERIPHERAL BLOOD OF PATIENTS WITH ALZHEIMER'S DISEASE
L. Fernández-Novoa¹, I. Etcheverría², S. Seoane¹, R. Cacabelos³, V. Lombardi^2
1EBIOTEC, Molecular Genetics, Bergondo, Spain, ²EBIOTEC, Cellular Immunology, Bergondo, Spain, ³Euroespes Biomedical Research Center, Clinical Neuroscience, Bergondo, Spain

INDOLEAMINE 2,3 DIOXYGENASE AS A LINK BETWEEN NEUROINFLAMMATION AND DEPRESSION IN ALZHEIMER'S DISEASE?
N. Dobos¹, E. de Vries², J. Korf³, U. Eisel¹, I. Nijholt^1
1University of Groningen, Department of Molecular Neurobiology, Haren, Netherlands, ²University of Groningen, Nuclear Medicine and Molecular Imaging, Groningen, Netherlands, ³University of Groningen, Biological Psychiatry, Groningen, Netherlands

INFLAMMATORY CYTOKINES INTERLEUKIN-10 AND INTERLEUKIN-1β GENE POLYMORPHISMS AND PARKINSON'S DISEASE IN ITALIAN PATIENTS
E. Pascale¹, C. Purcaro², E. Passarelli³, F. Passarelli¹, P. Stirpe², E. Di Battista², G. Meco^2
1University 'la Sapienza', Department of Experimental Medicine and Pathology, Rome, Italy, ²University 'la Sapienza', Department of Neurological Sciences, Rome, Italy, ³University 'la Sapienza', Rome, Italy

PROTECTIVE EFFECT OF PUTATIVE DRUG CANDIDATES ON THE AMYLOID-BETA OLIGOMER-INDUCED ASTROCYTE ACTIVATION IN RAT ENTORHINAL CORTEX
D. Simon, E. Borbely, E. Sipos, K. Soós, B. Penke, L. Fulop
University of Szeged, Department of Medical Chemistry, Szeged, Hungary

EFFECT OF AN INHIBITION OF TNFα ON COGNITIVE DEFICITS IN AN ANIMAL MODEL OF ALZHEIMER'S DISEASE
F. Chavant¹, A. Rioux Bilan², J. Deguil², C. Lafay-Chebassier¹, S. Pain², B. Fauconneau², M.-C. Pérault-Pochat^1
1Poitiers University Hospital, Clinical Pharmacology, Poitiers, France, ²Poitiers University, Research Group on Brain Aging (EA 3808), Poitiers, France

MICROGLIAL UPTAKE OF AMYLOID-ß AND INFLAMMATORY ACTIVITY ARE DETERMINED BY AMYLOID-ß AGGREGATION STATE AND EXPRESSION OF INNATE IMMUNITY RECEPTORS
R. Schomburg, K. Faßbender
University of the Saarland, Department of Neurology, Homburg / Saar, Germany

TRANSCRIPTOMIC ANALYSIS REVEALS DISTURBED INFLAMMATORY AND APOPTOTIC RESPONSE IN LIPID-LADEN HUMAN NIEMANN-PICK DISEASE TYPE C MACROPHAGES
K. Leuthaeuser-Jaschinski¹, E. Orsó¹, H.-H. Klünemann², G. Schmitz^1
1University Hospital Regensburg, Institute for Clinical Chemistry and Laboratory Medicine, Regensburg, Germany, ²Regensburg University Medical Center, Department of Psychiatry, Regensburg, Germany

THE ROLE OF NEUROINFLAMMATION ON BDNF PRODUCTION IN MILD COGNITIVE DISORDER AND ALZHEIMER'S DISEASE
P. Naudé¹, I. Nijholt¹, P. Luiten¹, H. Den Boer², U. Eisel^1
1University of Groningen, Molecular Neurobiology, Haren, Netherlands, ²University of Groningen, Biological Psychiatry, Groningen, Netherlands

AMYLOID-BETA PEPTIDE INDUCES HIF TRANSCRIPTION FACTOR AND VEGF EXPRESSION IN CULTURED NORMAL ADULT HUMAN ASTROCYTES
A. Chiarini¹, U. Armato¹, M. Marconi¹, R. Pacchiana¹, C. Bonafini¹, B. Chakravarthy², J.F. Whitfield², I. Dal Pra^1
1Histology & Embryology, Biomedical & Surgical Sciences, Verona, Italy, ²Biological Sciences, National Reasearch Council of Canada, Ottawa, Canada

ACTIVATION OF MICROGLIA IN ALZHEIMER'S DISEASE FOLLOWING Aβ42 IMMUNISATION: GOOD OR BAD?
D. Boche¹, E. Zotova¹, C. Holmes¹, J. Neal², D. Wilkinson³, J. Nicoll^1
1University of Southampton, Division of Clinical Neurosciences, Southampton, United Kingdom, ²University of Wales, Department of Pathology, Cardiff, United Kingdom, ³MARC Moorgreen Hospital, Southampton, United Kingdom

THE ROLE OF BETA-AMYLOID AND INFLAMMATION IN TRIGGERING ABERRANT NEURONAL CELL CYCLE EVENTS
N. Varvel¹, K. Bhaskar¹, K. Herrup², B. Lamb^1
1Cleveland Clinic, Neurosciences, Cleveland, United States, ²Rutgers, The State University of New Jersey, Cell Biology and Neuroscience, Piscataway, United States

RAG-1 DEFICIENCY ENHANCES AMYLOID PLAQUE FORMATION IN AN ALZHEIMER TRANSGENIC MOUSE MODEL
L. Katsouri, K. Thanopoulou, M. Kanakari, S. Georgopoulos
Biomedical Research Institute, Academy of Athens, Athens, Greece

CD14 MEDIATES MICROGLIAL ACTIVATION BY FIBRILLAR Aβ
E. Reed-Geaghan, P. Cramer, G. Landreth
Case Western Reserve University, Neuroscience, Cleveland, United States

EFFECTS OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) ON AMYLOID PATHOLOGY IN MUSCLE
T.L. Beckett, R.L. Webb, M.P. Murphy
University of Kentucky, Biochemistry, Sanders Brown Center on Aging, Lexington, United States

ASSOCIATION OF GENETIC VARIATION OF CRP WITH ALZHEIMER'S DISEASE-RELATED SENILE PLAQUES AND NEUROFIBRILLARY TANGLES
E. Kok¹, M. Alanne², S. Haikonen¹, T. Luoto¹, H. Huhtala³, L. Viiri¹, K. Kristiansson², M. Hurme⁴, H. Haapasalo⁵, M. Perola², P. Karhunen^1
1University of Tampere, Forensic Medicine, Tampere, Finland, ²National Public Health Institute, Molecular Medicine, Helsinki, Finland, ³University of Tampere, School of Public Health, Tampere, Finland, ⁴University of Tampere, Immunology, Tampere, Finland, ⁵Tampere University Hospital, Pathology, Centre for Laboratory Medicine, Tampere, Finland

INFLAMMATORY BIOMARKERS ARE ASSOCIATED WITH LOW IGF-I LEVELS AND DISABILITY IN ALZHEIMER'S DISEASE
A. Alvarez, C. Sampedro, R. Cacabelos
EuroEspes Biomedical Research Centre, A Coruña, Spain

NAÏVE (PD1^NEG) AND ACTIVATED (PD1^POS) CD4+ T REGULATORY CELLS IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD)
M. Saresella¹, I. Marventano¹, E. Calabrese², R. Nemni³, R. Mancuso¹, F.R. Guerini¹, M. Clerici^4
1Don Gnocchi ONLUS Foundation IRCCS, Laboratory of Molecular Medicine and Biotechnology, Milan, Italy, ²Don Gnocchi ONLUS Foundation IRCCS, Neurology Unit, Milan, Italy, ³Chair of Neurology, Department of Biomedical Sciences and Technologies, University of Milan and Neurology Unit, Don C. Gnocchi ONLUS Foundation, IRCCS, Milan, Italy, ⁴Chair of Immunology, Department of Biomedical Sciences and Technologies, University of Milan, and Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi ONLUS Foundation IRCCS, Milan, Italy

LPS-INDUCED NO PRODUCTION IN MURINE BV-2 CELLS IS DEPENDENT ON THE JNK PATHWAY
C. Pettersson¹, K. Reis¹, S. Zetterström Fernaeus², T. Land^2
1Stockholm University, Neurochemistry, Stockholm, Sweden, ²Tallinn University, Tallinn, Estonia

RUNNING EXERCISE PROTECTS DOPAMINERGIC NEURONS AGAINST NEUROINFLAMMATION-INDUCED DEGENERATION
T.-F. Wang, S.-Y. Wu, C.-W. Wu, Y.-M. Kuo
National Cheng Kung University, Department of Cell Biology & Anatomy, Tainan, Taiwan, Republic of China

ENDOTHELIN 1 REDUCES P-GLYCOPROTEIN TRANSPORT ACTIVITY IN A HUMAN ADULT IN VITRO BLOOD BRAIN BARRIER MODEL
A. Hembury¹, A. Mabondzo^2
1CEA, Gif sur Yvette, France, ²CEA, Institut de Biologie et de Technologie de Scalay, Gif sur Yvette, France

LYMPHOPENIA IN IDIOPATHIC PARKINSONISM: AN AETIOLOGICAL CLUE
J. Bowthorpe¹, A. Charlett², C. Weller¹, R.J. Dobbs³, S.M. Dobbs^3
1Institute of Psychiatry, Kings College London, London, United Kingdom, ²Centre for Infections, Health Protection Agency, London, United Kingdom, ³Institute of Psychiatry, Kings College London, Department of Gastroenterology, Kings College Hospital, London, United Kingdom

PROSTAGLANDIN J2: A PRODUCT OF INFLAMMATION THAT CAUSES ALZHEIMER'S- AND PARKINSON'S-LIKE PATHOLOGY
M. Figueiredo-Pereira
Hunter College of City University of New York, Biological Sciences, New York, United States

IMMUNO-INFLAMMATORY ACTIVATION AS A CAUSE OF INCREASED SERUM HOMOCYSTEINE CONCENTRATION IN IDIOPATHIC PARKINSONISM
R.J. Dobbs¹, A. Charlett², C. Weller³, S. Dobbs¹, I.T. Bjarnason^4
1Institute of Psychiatry, Kings College London, Department of Gastroenterology, Kings College Hospital, London, United Kingdom, ²Centre for Infections, Health Protection Agency, Statistics Unit, London, United Kingdom, ³Institute of Psychiatry, Kings College London, London, United Kingdom, ⁴Kings College London, Department of Gastroenterology, London, United Kingdom

TIME TRENDS IN FACETS OF IDIOPATHIC PARKINSONISM DISSOCIATE FOLLOWING HELICOBACTER ERADICATION: AN EXPLANATION FOR HYPOKINESIA- AND RIGIDITY-PREDOMINANT SYNDROMES
S. Dobbs¹, R.J. Dobbs¹, C. Weller², A. Charlett³, I.T. Bjarnason^4
1Institute of Psychiatry, Kings College London, Department of Gastroenterology, Kings College Hospital, London, United Kingdom, ²Institute of Psychiatry, Kings College London, London, United Kingdom, ³Centre for Infections, Health Protection Agency, Statistics Unit, London, United Kingdom, ⁴Kings College London, Department of Gastroenterology, London, United Kingdom

STIMULATING SIGNALING PATHWAY LEADING TO CREB-MEDIATED TARGET GENE TRANSCRIPTION RELATED TO LEARNING AND MEMORY IN HIPPOCAMPUS OF TOLUENE-EXPOSED MICE
H. Fujimaki¹, T.-T. Win-Shwe¹, S. Yamamoto¹, N. Kunugita², K. Arashidani^2
1National Institute for Environmental Studies, Tsukuba, Japan, ²University of Occupational and Environmental Health, Japan, Kitakyushu, Japan

PROLINE-RICH POLYPEPTIDE COMPLEX (PRP) FROM OVINE COLOSTRUM REGULATES ACTIVITY OF INDUCIBLE NITRIC OXIDE SYNTHASE
A. Zabłocka¹, A. Ogorzalek², M. Janusz^3
1Institute of Immunology and Experimental Therapy, Polish Academy of Science, Immunochemistry, Wroclaw, Poland, ²Institute of Zoology, University of Wroclaw, Wroclaw, Poland, ³Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wroclaw, Poland

DEXAMETHASONE SIGNIFICANTLY MODIFIED STRIATAL DOPAMINERGIC, GLUTAMATERGIC AND GABAERGIC NEUROTRANSMISSIONS IN NORMAL AND RAT MODEL OF PARKINSON'S DISEASE
M. Shafiee Ardestani¹, S. Jazaeri², M. Saffari^3
1Tehran University of Medical Sciences, Faculty of Pharmacy, Department of Radiopharmacy & Medicinal Chemistry, Tehran, Iran, Islamic Republic of, ²Azad University of Medical Sciences, Faculty of Pharmacy, Department of Pharmacology, Tehran, Iran, Islamic Republic of, ³Shahid Beheshti University of Medical Sciences, Faculty of Pharmacy, Department of Pharmmaceutics, Tehran, Iran, Islamic Republic of

TISSUE PLASMINOGEN ACTIVATOR (TPA) INDUCES MICROGLIA ACTIVATION THROUGH A MOLECULAR MECHANISM INVOLVING ERK1/2 ACTIVATION
D. Pineda¹, M.G. Medina¹, C. Ampurdanes¹, J. Saura², J.M. Tusell³, J. Serratosa³, P. Navarro^1
1IMIM, Cancer Program, Barcelona, Spain, ²University of Barcelona, UB-IDIBAPS, Biochemistry Unit. School of Medicine, Barcelona, Spain, ³IIBB-CSIC, IDIBAPS, Department of Cerebral Ischemia and Neurodegeneration, Barcelona, Spain