|
SUNDAY,
SEPTEMBER 29, 2002 |
MONDAY,
SEPTEMBER 30, 2002 |
TUESDAY,
OCTOBER 1, 2002 |
WEDNESDAY,
OCTOBER 2, 2002 |
THURSDAY,
OCTOBER 3, 2002 |
| Orals |
Orals
|
Posters |
Orals
|
Posters |
Orals
|
Posters
|
Orals
|
Posters
|
| MONDAY, SEPTEMBER 30,
2002 |
| 08:30 - 09:15 |
Hall A |
| PLENARY SESSION:
HISTORY AND THE FUTURE OF APS |
| Supported by an unrestricted
educational grant from Novartis Pharma AG, Switzerland |
Chairpersons:
|
G.R.V. Hughes, UK
C. Plotz, USA |
| 08:30 |
A HISTORICAL POINT OF VIEW
M-C. Boffa, France |
| 08:55 |
APS: THE PAST, THE PRESENT AND THE FUTURE
D. Alarcon-Segovia, Mexico |
| |
| 09:15 - 10:00 |
Hall A |
| PATHOGENIC
MECHANISMS I |
| Supported by an unrestricted
educational grant from Alfa Wassermann S.p.A., Italy |
Chairpersons:
|
J. Arnout, Belgium
G. De Groot, The Netherlands |
| 09:15 |
ANNEXIN
A2 AND THE UPREGULATION OF MONOCYTE TISSUE FACTOR ACTIVITY
BY aPL
H. Zhou, R.A.S. Roubey, USA |
| 09:30 |
TFPI
ACTIVITY AND ANTI-TFPI ANTIBODIES IN APS
I.J Mackie, B. Cakir, R. Roubey, M. Adams, S.J Machin,
UK, USA |
| 09:45 |
COMPLEMENT
COMPONENT C5 ACTIVATION IS REQUIRED FOR
aPL-INDUCED PREGNANCY LOSS
G. Girardi, M. Holers, J. Salmon, USA |
| 10:00 Coffee Break, Poster
Viewing and Exhibition Visit |
| |
| 10:30 - 12:30 |
Hall A |
| GENETICS AND
APS |
| Supported by an unrestricted
educational grant from Aventis Boehring, Germany |
Chairpersons:
|
D. Alarcon-Segovia, Mexico
A. Wilson, USA |
| 10:30 |
ETHNIC
AND GEOGRAPHIC ASPECTS OF APS
W. Wilson, A. Gharavi, USA |
| 10:50 |
HLA-DPB1
ALLELES ASSOCIATION OF ANTICARDIOLIPIN AND ANTI-BETA2GPI ANTIBODIES
IN A LARGE SERIES OF EUROPEAN PATIENTS WITH SLE
G.D. Sebastiani, M. Galeazzi, A. Tincani, R. Scorza,
A. Mathieu,
G. Passiu, G. Morozzi, J.C. Piette, R. Cervera, F. Houssiau,
J. Smolen,
A. Fernandez Nebro, E. De Ramon, A. Jedryka Goral, J. Font,
C. Papasteriades, R. Marcolongo, Italy, France, Spain, Belgium,
Austria, Poland, Greece |
| 11:00 |
GLYCOPROTEIN
IIIA POLYMORPHISM HPA6Wa/b AND aPL ARE INDEPENDENT RISKS FOR
THROMBOCYTOPENIA IN PATIENTS WITH SLE
O. Amengual, T. Atsumi, Y. Komano, S. Jodo, Y. Amasaki,
K. Ichikawa,
T. Koike, Japan |
| 11:10 |
A
FUNCTIONAL B2GPI PROMOTER POLYMORPHISM IS ASSOCIATED WITH
REDUCED GENE EXPRESSION AND PLASMA LEVELS
H. Mehdi, S. Manzi, P. Desai, Q. Chen, X. Wang, S. Strom,
R. Zarnegar,
M.I. Kamboh, USA |
| 11:20 |
aPL
SYNDROME AND GENETIC FORMS OF THROMBOPHILIA AS A CAUSE OF
FETAL LOSS SYNDROME
A.D. Makatsaria, T.V. Matveeva, V.O. Bitsadze, O.S.
Alyautdina,
N.V. Dolgushina, D.V. Salickram, Russia |
| 11:30 |
MAJOR
HISTOCOMPATIBILITY COMPLEX POLIMORPHISM IN APS
M.B. Rodriguez Cardozo, C.G. Echenique, N.I. Ribas,
D.S. Fernandez Romero, J.U. Scher, J.O. Latino, M.
Pesaresi, A.M. Lonardo, Argentina |
| 11:40 |
FREQUENCY
OF B2GPI POLYMORPHISMS IN AN IRISH POPULATION
F. Lin, C. Feighery, J. Jackson, Ireland |
| 11:50 |
P-SELECTIN
GLYCOPROTEIN LIGAND-1 POLYMORPHISMS AND DEVELOPMENT OF THROMBOSIS
IN THE APS
R. Diz-Kucukkaya, M. Inanc, V. Afshar-Kharghan, J.A.
Lopez,
Y. Pekcelen, Turkey, USA |
| 12:00 |
PREVALENCE
OF APS IN TWO SLE CLINICS OF MIXED RACIAL POPULATION
E.M.N. Albuqerque, V.S. Viela, A.C. Fonseca, M.I.D. Souto,
D.S. Silveira, E.M. Klumb, J.A.S. Papi, R.A. Levy,
Brazil |
| 12:10 |
INFLAMMATORY
ELEMENTS AND THE APS
E. Rewald, Argentina
|
| 12:20 |
BIOPSY
PROVEN AND BIOPSY NEGATIVE GIANT CELL ARTERITIS (GCA) : ARE
aCL VIRUS-INDUCED ? A PROSPECTIVE, MULTICENTER CASE-CONTROL
STUDY
P. Duhaut, S. Bosshard, M. Berruyer, D. Le Thi Huong,
M. L. Boncors,
D. Seydoux, H. Pellet, J. P. Ducroix, J. C. Piette, France |
12:30 Lunch Break, Poster Viewing
and Exhibition Visit
|
| |
| 10:30 - 12:40 |
Hall B |
| SYSTEMIC INVOLVEMENT
IN APS |
| Supported by an
unrestricted educational grant from The Methodist Health Foundation
and Clarian Health Partners, USA |
Chairpersons:
|
S. Bombardieri, Italy
J.A. McIntyre, USA |
| 10:30 |
EURO-PHOSPHOLIPID
PROJECT
R. Cervera, Spain |
| 10:45 |
aPL
AND RENAL TRANSPLANTATION: A RISK ASSESSMENT
J.A. McIntyre, D.R. Wagenknecht, USA |
| 11:00 |
ECHOCARDIOGRAPHY,
PULMONARY FUNCTION TESTING AND INDUCED SPUTUM EVALUATION IN
SLE AND THE APS
D. Paran, B. Koifman, O. Elkayam, D. Levartovsky, I.
Kaufman, D. Caspi,
M. Yaron, E. Fireman, Y. Schwarz, Israel |
| 11:10 |
LUPUS
ANTICOAGULANT PROJECT OF THE ITALIAN FEDERATION OF ANTICOAGULATION
CLINICS
A. Biasiolo, A. Tripodi, V. Chantarangkul, M. Galli, V.
Pengo, Italy |
| 11:20 |
ASSOCIATION
OF aPL AND VALVULAR HEART DISEASES IN JAPANESE PATIENTS WITH
AUTOIMMUNE DISEASES
Y. Sakai, T. Atsumi, S. Furukawa, M. Ieko, S. Jodo,
Y. Amasaki,
K. Ichikawa, T. Koike, Japan |
| 11:30 |
LONG-TERM
FOLLOW-UP OF ANTIPHOSPHOLIPID POSITIVE PATIENTS (aPL+) WITH
LUPUS NEPHRITIS
G. Moroni, P. Panzeri, G. Banfi, D. Ventura, P. Riva, R. Bader,
P.L. Meroni, C. Ponticelli, Italy |
| 11:40 |
IDIOPATIC
LIVEDO RETICULARIS SYNDROME AND THROMBOSIS (APS-aPL NEGATIVE)
J. Ordi, F. Martinez, E. Balada, T. Molins, A. Martin,
M. Vilardell, Spain |
| 11:50 |
aPL
AND OSTEONECROSIS: A STUDY OF SLE AND PAPS PATIENTS
L. Praderio, G. Brambilla, G. Di Comite, G. Minutiello,
S. Panza,
A. Pedrocchi, M.G. Sabbadini, Italy |
| 12:00 |
ADRENAL
INVOLVEMENT IN APS
G. Espinosa , E. Santos, R. Cervera, J. Font, R.A.
Asherson, M. Ingelmo, Spain, South Africa |
| 12:10 |
aCL
ARE ASSOCIATED WITH PRIMARY PULMONARY HYPERTENSION AND HISTORY
OF THROMBOSES IN SYSTEMIC SCLEROSIS
C. Antonioli, E. Danieli, C. Tedoldi, I. Cavazzana,
L. Bettoni, P. Airo',
F. Allegri, R. Cattaneo, A. Tincani, Italy |
| 12:20 |
THE
PERSISTENCE OF aPL IN SUDDEN SENSORINEURAL HEARING LOSS
A. Kessel, M. Luntz, J. Ben-David, K. Hallas, E. Toubi,
Israel |
| 12:30 |
PRIMARY
ANETODERMA - A CUTANEOUS SIGN OF APLA
E. Hodak, H. Feuerman, Y. Molad, Y. Monselise, M. David,
Israel |
| 12:40 Lunch Break,
Poster Viewing and Exhibition Visit |
| |
| 12:30 - 14:00 |
Hall C |
SATELLITE
SYMPOSIUM: NOVELTIES FROM NATURE:
A PROMISING NATURAL COMPOUND |
| Supported by an unrestricted
educational grant from AFR srl, Italy |
Chairperson::
|
P.L. Meroni, Italy |
| 12:30 |
FREE RADIACLS AND IMMUNE SYSTEM
F. Nicoletti, Italy |
| 12:40 |
NUTRITIONAL HABITS AND GUIDELINES FOR PREVENTION
OF TUMORS AND IMMUNE DISEASE
G. Scapagnini, Italy |
| 12:50 |
AVEMAR
-(A NEW BENZOQUINONE-CONTAINING NATURAL PRODUCT) ADMINISTRATION
INTERFERES WITH THE Th2 RESPONSE IN EXPERIMENTAL SLE AND PROMOTES
AMELIORATION OF THE DISEASE
M. Ehrenfeld, M. Blank, M. Hidvegi, Israel, Hungary |
| 13:00 |
DISCUSSION AND FINAL CONSIDERATIONS
Y. Shoenfeld, Israel |
| 13:10 |
QUESTION TIME |
| 13:20 |
PRESS CONFERENCE
Y. Shoenfeld, Israel
M. Hidvegi, Hungary
S.G. Sukkar, Italy |
| |
| 14:00 - 16:00 |
Hall A |
| ANTI-PROTHROMBIN
ANTIBODIES (APT) |
| Supported by an unrestricted
educational grant from Bio-Rad Laboratories, USA |
Chairpersons:
|
D.A. Triplett, USA
M. Galli, Italy |
| 14:00 |
LABORATORY
DIAGNOSIS OF LA/aPL
D.A. Triplett, USA |
| 14:10 |
aPT:
PREVALENCE AND ASSOCIATION WITH aCL, ANTI-B2GPI, LA, AND CLINICAL
CORRELATES
G. Obermoser, M. Abenthung, G. Margreiter, N. Sepp,
Austria |
| 14:20 |
PREVALENCE
AND HETEROGENEITY OF IgG-ANTI-PROTHROMBIN ANTIBODIES IN PATIENTS
WITH HISTORY OF THROMBOSIS
N. Bardin, M.C. Alessi, F. Dignat-George, I. Juhan-Vague,
J. Sampol,
M. Sanmarco, France |
| 14:30 |
A
MONOCLONAL ANTIBODY AGAINST PROTHROMBIN FRAGMENT 2 BEHAVES
LIKE A LUPUS ANTICOAGULANT
J. Arnout, D. Boon, P. Vandervoort, M. Vanrusselt,
J. Vermylen, Belgium |
| 14:40 |
aPTs
INDUCE THROMBOSIS IN AN ANIMAL MODEL OF APS
S. Haj-Ichya, Y. Sherer, M. Blank, Y. Shoenfeld, Israel |
| 14:50 |
ANTIBODIES
AGAINST PHOSPHATIDYLSERINE-PROTHOROMBIN COMPLEX ARE INVOLVED
IN THE PATHOGENESIS OF LUPUS ANTICOAGULANT
J. Arai, M. Ieko, T. Atsumi, S. Naitoh, M. Takeda,
T. Tarumi,
T. Nakabayashi, T. Koike, Japan |
| 15:00 |
aPT
AND ANTI-ANNEXIN V ANTIBODIES ARE ASSOCIATED WITH THROMBOSIS
IN SLE PATIENTS, AND FETAL LOSS IN WOMEN WITH RECURRENT ABORTION
N. Bizzaro, D. Villalta, E. Tonutti, M. Tampoia, R.
Tozzoli, A. Biasiolo,
V. Pengo, Italy |
| 15:10 |
FUNCTIONAL
ANALYSIS OF THE ROLES OF PROTHROMBIN AND B2GPI IN aPL-INDUCED
ABNORMAL TRANSMITTANCE WAVEFORMS
Z. Su, T. Izumi, T.L. Ortel, USA, Japan |
| 15:20 |
COMPARISON
OF THE EFFECTS OF ANTI-B2GPI AND ANTI-PROTHROMBIN ANTIBODIES
ON PLATELET ADHESION IN AN IN VITRO FLOW SYSTEM
B.C.H. Lutters, R.H.W.M. Derksen, W.L. Tekelenburg,
J. Arnout,
P.G. De Groot, The Netherlands, Belgium |
| 15:30 |
ANTIBODIES
AGAINST PROTHROMBIN AND ANNEXIN V
B. Bozic, S. Cucnik, N. Gaspersic, A. Ambrozic, B.
Rozman, T. Kveder, Slovenia |
| 15:40 |
FREQUENCY
OF ANTIBODIES TO CARDIOLIPIN AND PHOSPHOLIPID-RELATED PROTEINS
(B2GPI, PROTHROMBIN, ANNEXIN V) IN A HEALTHY POPULATION COMPARED
TO GROUPS OF PATIENTS WITH SYSTEMIC RHEUMATIC DISEASES, DEEP
VEIN THROMBOSIS OR FETAL LOSS
W. Huebl, B. Fabian, K. Frischmuth, A. Griesmacher, P.M.
Bayer, Austria |
| 15:50 |
IgG
IgM AND IgA ANTIPHOSPHOLIPID B2GPII AND ANTIPROTHROMBIN ANTIBODIES
IN SLE PATIENTS
R.A. Asherson, S. Singh, T. Gould, E. Wypkema, M. Tikly,
S. Loizou,
South Africa, Greece |
| 16:00 Coffee Break, Poster
Viewing and Exhibition Visit |
| |
| 14:00 - 16:00 |
Hall B |
| DIAGNOSTICS,
SCREENING, PROGNOSIS AND OTHER DISEASES |
| Supported by an unrestricted
educational grant from Louisville APL Diagnostics, Inc., USA |
Chairpersons:
|
R.H.W.M. Derksen, The Netherlands
P. Youinou, France |
| 14:00 |
DECIPHERING LABORATORY TESTS FOR THE APS
(A JOURNEY TRHOUGH THE UNDERBUSH)
E.N. Harris, USA |
| 14:20 |
ANTIPHOSPHOLIPID
AND OTHER ELISA TESTS FOR DIAGNOSIS OF APS: UN UPDATE
S.S. Pierangeli, E.N. Harris, USA |
| 14:30 |
OBSERVATIONS
USING NAILFOLD VIDEOCAPILLAROSCOPY IN PRIMARY APS
J.L.P. Vaz, R.A. Levy, E.M.N. Albuquerque, M.A.A. Dancour,
D.A. Bottino, E. Bouskela, Brazil |
| 14:40 |
LUPUS
ANTICOAGULANTS AND THROMBOSIS:
A FORMAL ESTIMATION OF THE RISK
M. Galli, D. Luciani, G. Bertolini, T. Barbui, Italy |
| 14:50 |
ANTICOAGULANTS
G. Agnelli, Italy |
| 15:00 |
RATIONALE
FOR SEQUENTIAL aPL TESTING AND DIAGNOSIS OF APS: SURVEY RESULTS
IN TWO USA GROUPS VS. ISAPA COMMITTEE RESPONDENTS 2000-2002
G.A. McCarty, T.E. Cason, USA |
| 15:10 |
DETECTION
OF aPL IN PATIENTS WITH PRIMARY BILIARY CIRRHOSIS AND AUTOIMMUNE
HEPATITIS
P. von Landenberg, R. Schlichting, J. Schoelmerich,
G. Lock, Germany |
| 15:20 |
NEW
VARELISA ANTI-CARIOLIPIN AND ANTI-B2GPI ANTIBODY
ASSAYS IN THE SCREENING OF APS
B. Gilburd, M. Blank, Y. Shoenfeld, Israel |
| 15:30 |
DIMERS
OF B2GPI INDUCE INCREASED PLATELET ADHESION AND THROMBUS FORMATION
IN FLOWING BLOOD
B.C.H. Lutters, R.H.W.M. Derksen, W.L. Tekelenburg,
J. Arnout,
P.G. De Groot, The Netherlands, Belgium |
| 15:40 |
IN
VITRO DETECTION OF T LYMPHOCYTE RESPONSESTO CARDIOLIPIN AND/OR
PHOSPHATIDYLINOSITOL IN PATIENTS WITH APS
B. Cauquelin, E. Comby, A. Lequerrec, C. Lehello, P.
Letellier, J.J. Ballet, France |
| 15:50 |
LONG-TERM
FOLLOW-UP IN 128 PATIENTS WITH PRIMARY APS (PAPS). DO THEY
DEVELOP LUPUS?
M-C. Amigo, J.A. Gomez-Puerta, H. Martin, M.A. Aguirre,
M.T. Camps,
M.J. Cuadrado, M.A. Khamashta, G.R.V. Hughes, Mexico, Spain,
UK
|
| 16:00 Coffee Break, Poster
Viewing and Exhibition Visit |
| |
| 16:30 - 18:00 |
Hall A |
| CATASTROPHIC
APS |
| Supported by an unrestricted
educational grant from BMD, France |
Chairpersons:
|
R.A. Asherson, South Africa
J.C. Piette, France |
| 16:30 |
INTRODUCTORY COMMENTS
J.C. Piette, France |
| 16:40 |
CATASTROPHIC
APS: CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF 130 PATIENTS
R.A. Asherson, R. Cervera, J.C. Piette, Y. Shoenfeld,
G. Espinosa,
M. Garcia-Carrasco, M. Ramos-Casals, J. Font, M. Ingelmo,
South Africa, Spain, France, Israel |
| 17:00 |
LEG
AMPUTATION - POSSIBLE THERAPEUTIC ROLE IN CATASTROPHIC APS
(CAPS)
H. Amital, Y. Levy, P. Langevitz, A. Rubinow, Y. Shoenfeld,
Israel, UK |
| 17:20 |
THE
LONG-TERM FOLLOW-UP OF CAPS SURVIVORS
D. Erkan, G. Espinosa, R. Cervera, M.D. Lockshin, R.A.
Asherson, USA, Spain, South Africa |
| 17:40 |
MANAGEMENT OF THROMBOSIS, EMPHASIZE ON CATASTROPHIC
APS
M. Khamashta, UK |
| 17:50 |
DISCUSSION |
| |
| 16:30 - 18:10 |
Hall B |
| PEDIATRIC
APS AND EPILEPSY |
| Supported by an unrestricted
educational grant from American Diagnostica, USA |
Chairpersons:
|
P.L. Meroni, Italy
M. Lorber, Israel |
| 16:30 |
APS
IN CHILDREN WITH SYSTEMIC AUTOIMMUNE DISEASE
I. Hadacova, P. Vavrincova, E. Hladikova, M. Sukova, J.
Vavrinec,
Czech Republic |
| 16:40 |
TRANSITORY
PRODUCTION OF ANTI-B2GPI ANTIBODIES (ANTI-B2GPI) IN INFANTS
WITH ATOPIC DERMATITIS: NEW EVIDENCE SUPPORTING THE ROLE OF
DIETARY B2GPI
T. Avcin, A. Ambrozic, B. Bozic, M. Kuhar, T. Kveder,
B. Rozman, Slovenia |
| 16:50 |
ANTIBODIES
TO CARDIOLIPIN IN KAWASAKI DISEASE
E. Grunebaum, M. Blank, S. Cohen, Y. Shoenfeld, Israel |
| 17:00 |
ELECTROPHYSIOLOGICAL
EVALUATION OF PATIENTS WITH THE APS AND ASSOCIATED CNS MANIFESTATIONS
AS COMPARED TO PATIENTS WITH MULTIPLE SCLEROSIS
D. Paran, V. Drory, A.D. Korczyn, O. Elkayam, D. Levartovsky,
I. Litinsky,
D. Caspi, M. Yaron, Y. Segev, J. Chapman, Israel |
| 17:10 |
ANTI-CARDIOLIPIN
ANTIBODIES IN PATIENTS WITH EPILEPSY
I.I. Kokareshkova, D.M. Minchev, E.I. Konova, P.K.
Petrova, V.I. Yolova, Bulgaria |
| 17:20 |
ANTI-GANGLIOSIDE
ANTIBODIES IN EPILEPTIC PATIENTS
L. Crescibene, L. Bastone, A. Bagala', I.D. Napoli,
T. Ferraro, Italy |
| 17:30 |
ANTIBODIES
TO B2GPI PURIFIED FROM SEVERAL PATIENTS WITH RHEUMATIC FEVER
CROSS REACT WITH M PROTEIN OF STREPTOCOCCUS PYOGENES
L. Magrini, M. Blank, L. Guilherme, E. Grunebaum, J.
Kalil, H. Orbach,
F. Kvapil, Y. Shoenfeld, Israel, Brazil |
| 17:40 |
LUPUS
ANTICOAGULANT-HYPOPROTHROMBINEMIA SYNDROME PRESENTING AS A
MAJOR INTRAMUSCULAR HEMORRHAGE
Y. Uziel, J. Yacobovich, Z. Fridman, J. Radnay, B.
Wolach, Israel |
| 17:50 |
APS
CAN OCCUR IN CHILDREN, TOO: PROPOSAL FOR GUIDELINES IN THE
PEDIATRIC AGE
F. Falcini, R. Cimaz, T. Avcin, Italy, Slovenia |
18:00
|
PRIMARY
ANTIPHOSPHOLIPID SYNDROME IN PEDIATRIC AGE
M. Gattorno, A. Ravelli, F. Falicini, F. Zulian, A.
Martini, Italy |
| |
| 18:00 - 19:30 |
HALL B |
| PATIENTS'
SESSION |
Chairpersons:
|
P.L. Meroni, Italy
A. Tincani, Italy |
| |
INTRODUCTORY REMARKS
M-C. Boffa, France
D. Alarcon-Segovia, Mexico
G.R.V. Hughes, UK
|
| |
ROUND TABLE DISCUSSION
S. Bombardieri, Italy
R.L. Brey, USA
R. Cervera, Spain
R. Derksen, The Netherlands
M. Galli, Italy
M.A. Khamashta, UK
V. Pengo, Italy
J-C. Piette, France
G.D. Sebastiani, Italy
G. Valesini, Italy
|
SUNDAY,
SEPTEMBER 29, 2002 |
MONDAY,
SEPTEMBER 30, 2002 |
TUESDAY,
OCTOBER 1, 2002 |
WEDNESDAY,
OCTOBER 2, 2002 |
THURSDAY,
OCTOBER 3, 2002 |
| Orals |
Orals
|
Posters |
Orals
|
Posters |
Orals
|
Posters
|
Orals
|
Posters
|
|
|
