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| MONDAY,
MAY 6, 2002 |
| 08:00 -
08:30 |
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| WELCOME
AND GREETINGS |
| 08:30 -
09:20 |
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| PLENARY SESSION
1: HEILBRONN LECTURE |
| Chairperson: |
V.P. Whittaker, UK |
|
| 08:30 |
ACETYLCHOLINE
RECEPTORS: PROBING FUNCTIONALLY SIGNIFICANT STRUCTURAL CHANGES WITH
SITE-DIRECTED REACTIONS
A. Karlin, USA |
| 09:20 - 10:40 |
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| SESSION 1 |
| Chairperson: |
F.J. Barrantes, Argentina |
|
| 09:20 |
THE
CRYSTAL STRUCTURE OF MOLLUSCAN ACHBP REVEALS THE LIGAND BINDING
DOMAIN OF THE NICOTINIC ACETYLCHOLINE RECEPTOR
K. Brejc, W.J. van Dijk, R.V. Klaassen, M. Schuurmans,
J. van der Oost, A.B. Smit, T.K. Sixma, The Netherlands |
| 09:40 |
THE
BINDING SITE OF ACETYLCHOLINE RECEPTOR: FROM SYNTHETIC PEPTIDES
TO SOLUTION AND CRYSTAL STRUCTURE
S. Fuchs, R. Kasher, M. Balass, T. Scherf, M. Harel, A. Nicolas,
M. Fridkin, J.L. Sussman, E. Katchalski-Katzir, Israel |
| 10:00 |
STRUCTURAL STUDIES ON THE
NICOTINIC ACETYLCHOLINE RECEPTOR
Y. Paas, France |
| 10:20 |
MOLECULAR
BASIS OF THE SELECTIVITY OF NEUROTOXINS TOWARDS nAcHR SUBTYPES
D. Servent, C. Gaillard, B. Gilquin, S. Antil-Delbeke,
P.J. Corringer, J.P. Changeux, A. Menez, France |
| 10:40 |
Coffee Break and Poster
Viewing |
| 11:10 - 12:50 |
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| SESSION 2 |
| Chairperson: |
D. Bertrand, Switzerland |
|
| 11:10 |
ALLOSTERISM
OF THE NICOTINIC ACETYLCHOLINE RECEPTOR
F. Hucho, G.M. Bixel, M. Krauss, Germany |
| 11:30 |
STRUCTURE
AND DYNAMICS OF ACETYLCHOLINE RECEPTOR AND ITS LIPID MICROENVIRONMENT:
MOLECULE TO CELL
S. Antollini, J. Baier, M. Blanton, I. Bonini, B. De los Santos,
M.C. Gallegos, I. Garbus, M.F. Pediconi, M. Prieto, A.M. Roccamo,
J. Wenz, F.J. Barrantes, Argentina |
| 11:50 |
SITE-DIRECTED
REACTIVE PROBES FOR STRUCTURAL AND FUNCTIONAL INVESTIGATION OF CHOLINERGIC
PROTEINS
F. Kotzyba-Hibert, S. Loudwig, C. Che, T. Grutter, A. Specht, A.
Mourot,
M. Goeldner, France |
| 12:10 |
NMR
STRUCTURE OF ALPHA-BUNGAROTOXIN IN COMPLEX WITH AN ACHR ALPHA-SUBUNIT
PEPTIDE REVEALS THE BASIS FOR SPECIES SPECIFIC RESISTANCE TO THE
TOXIN AND HOW ALPHA-NEUROTOXINS INHIBIT ACETYLCHOLINE BINDING TO
THE RECEPTO
A.O. Samson, E. Rodriguez, T. Scherf, J. Anglister, Israel
|
| 12:30 |
ACTIVATION INHIBITION AND UPREGULATION OF THE HUMAN NEURONAL NICOTINIC
ALPHA4/BETA2 RECEPTOR BY A PARTIAL AGONIST
V. Itier, D.C. Bertrand, Switzerland |
| 12:50 |
Lunch Break and Poster
Viewing |
| 14:45 - 16:25 |
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| SESSION 3 |
| Chairperson: |
S.C. Froehner, USA |
|
| 14:45 |
ORGANIZATION OF CYTOSKELETON OF MUSCLE FIBERS BY MUSCLE ACTIVITY
AND AGRIN
G. Bezakova, T.L Lomo, Switzerland, Norway |
| 15:05 |
THE
ROLE OF PSY1 NUCLEOTIDE RECEPTOR IN THE FORMATION OF NEUROMUSCULAR
JUNCTIONS
K.W.K. Tsim, E.A. Barnard, China, UK |
| 15:25 |
THE DYSTROPHIN COMPLEX - A SCAFFOLD FOR SIGNALING PROTEINS AT SYNAPSES
M.E. Adams, S.C. Froehner, USA |
| 15:45 |
AGRIN BLOCKADE IMPAIRS LATE BUT NOT INITIAL STAGES OF FUNCTIONAL
INNERVATION OF HUMAN MUSCLE IN VITRO
T. Mars, K. Mis, M.P. King, A.F. Miranda, Z. Grubic, Slovenia,
USA |
| 16:05 |
ORGANIZING ACETYLCHOLINESTERASE MOLECULES
AT THE NEUROMUSCULAR SYNAPSE
R.L. Rotundo, S.G. Rossi, J.M. Quintero, L.M. Kimbell, USA
|
| 16:25 |
Coffee Break and Poster
Viewing |
| 17:00 - 18:20 |
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| SESSION 4 |
| Chairperson: |
J. Massoulie, France |
|
| 17:00 |
THE
FUNCTIONAL HETERO-OLIGOMERIC FORMS OF CHOLINESTERASES
J. Massoulie, France |
| 17:20 |
TRANSCRIPTIONAL
AND POST-TRANSCRIPTIONAL EVENTS CONTROLLING EXPRESSION OF ACETYLCHOLINESTERASE
IN DEVELOPING AND ADULT MUSCLES
B.J. Jasmin, L.M. Angus, G. Belanger, J. Deschenes, F. Nassrallah,
Canada |
| 17:40 |
DENSITY
AND LOCALIZATION OF ACETYLCHOLINESTERASE IN VERTEBRATE NEUROMUSCULAR
JUNCTIONS
L. Anglister, Israel |
| 18:00 |
FOUR
ACETYLCHOLINESTERASE GENES IN THE NEMATODE CAENORHABDITIS ELEGANS
D. Combes, Y. Fedon, J-P. Toutant, M. Arpagaus, France |
| 20:30 - 21:50 |
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| SESSION
5 |
| Chairperson: |
H. Soreq, Israel |
| 20:30 |
THE MOLECULAR NEUROBIOLOGY
AND ACETYLCHOLINESTERASE VARIANTS: FROM STRESSFUL INSULTS TO ANTISENSE
INTERVENTION
H. Soreq, D. Glick, Israel |
| 20:50 |
TRANSCRIPTIONAL
CONTROL OF THE CHOLINERGIC GENE LOCUS (CGL):
A MOSAIC MODEL FOR REGULATION OF THE CHOLINERGIC PHENOTYPE
L.E. Eiden, B. Schuetz, M. Goerdes, C. Depboylu, M.K-H. Schafer,
E. Weihe, USA, Germany |
| 21:10 |
REGULATION OF CHOLINERGIC
GENE EXPRESSION BY NRSF/REST
M. Shimojo, L.B. Hersh, USA |
| 21:30 |
NEUROTRANSMITTER PHENOTYPE
SWITCH IN DEVELOPING NEURONS - GENOMIC AND PROTEOMIC APPROACHES
M. Linial, Y. Bledi, Y. Bogoch, Israel |
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