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| TUESDAY, MAY
7, 2002 |
| 08:30 - 09:20 |
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| PLENARY SESSION 2: COUTEAUX LECTURE |
| Chairperson: |
S. Tsuji, France |
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| 08:30 |
WANDERINGS
IN AND ABOUT ACTIVE SITE GORGES AND SUBUNIT INTERFACES
P. Taylor, B. Molles, J. Shi, S. Camp, Z. Radic, USA |
| 09:20 - 10:40 |
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| SESSION 6 |
| Chairperson: |
J.M. Gonzalez-Ros, Spain |
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| 09:20 |
REGULATION
OF NEUROTRANSMITTER RELEASE: CALCIUM AND ION CHANNELS
R. Rahamimoff, S. Kachalsky, N. Melamed-Book, I. Kaiserman,
R. Ahdut, A. Fendyur, A. Raveh, L. Shani, P. Blank, J. Coorsen,
J. Zimmerberg, Israel
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| 09:40 |
MACROMOLECULAR
ARCHITECTURE OF ACTIVE ZONE MATERIAL AND ITS ROLE IN SYNAPTIC TRANSMISSION
U.J. McMahan, USA |
| 10:00 |
PERSISTENT
AND TRANSIENT INHIBITION OF ACETYLCHOLINE RELEASE FROM MOTOR TERMINALS
BY BOTULINUM TOXIN A AND E ARE DUE TO THEIR CLEAVAGE PRODUCTS (SNAP-25
1-197 AND 1-180) HAVING DIFFERENT LIFE-TIMES
J.O. Dolly, G.O. Lisk, F.A. Meunier, N. Mohammed, P.G.P.
Foran, UK |
| 10:20 |
MEDIATOPHORE
NO LONGER AN ARTEFACT
M. Israel, Y. Dunant, France, Switzerland |
| 10:40 |
Coffee Break and Poster
Viewing |
| 11:10 - 12:50 |
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| SESSION 7 |
| Chairperson: |
I. Parnas, Israel |
|
| 11:10 |
MUSCARINIC
PRESYNAPTIC RECEPTORS ARE INVOLVED IN THE CONTROL OF THE TIME COURSE
OF NEUROTRANSMITTER RELEASE IN FROG AND MOUSE NEUROMUSCULAR JUNCTIONS
I. Parnas, I. Slutsky, H. Parnas, Israel |
| 11:30 |
STRUCTURAL
AND FUNCTIONAL CONSERVATION OF SNARE COMPLEXES
D. Fasshauer, W. Antonin, M. Margittai, S. Pabst, R. Jahn,
Germany |
| 11:50 |
GENETIC
DISSECTION OF SYNAPTIC FUNCTION IN DROSOPHILA
T.L. Schwarz, USA |
| 12:10 |
GENETIC
REGULATION OF CHOLINERGIC NEUROTRANSMITTER PHENOTYPES.
P.M. Salvaterra, M-H. Lee, S. Song, USA |
| 12:30 |
SIGNALING
PATHWAYS THAT REGULATE THE CHOLINERGIC GENE LOCUS EXPRESSION
B. Berse, I. Lopez-Coviella, T. Mellott, B.E. Slack, M.T.
Follettie, R.S. Thies, L. Li, J.K. Blusztajn, USA |
| 12:50 |
Lunch Break and Poster
Viewing |
| 14:45 - 16:25 |
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| SESSION 8 |
| Chairperson: |
P. Marchot, France |
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| 14:45 |
COMPARATIVE
STRUCTURAL STUDIES ON CONJUGATES OF TORPEDO CALIFORNICA AND
HUMAN ACETYLCHOLINESTERASES WITH ORGANOPHOSPHATE NERVE AGENTS
J.L. Sussman, C.B. Millard, G. Koellner, G. Kryger, M. Harel,
H. Greenblatt, H. Dvir, P. Bar-On, V. Neduva, K. Giles, A. Ordentlich,
Y. Segall, N. Ariel, D. Barak, B. Velan, A. Shafferman, L. Toker,
I. Silman, Israel |
| 15:05 |
CRYSTAL
STRUCTURE OF RECOMBINANT HUMAN BUTYRYLCHOLINESTERASE : NEW INSIGHTS
INTO THE CATALYTIC MECHANISMS OF CHOLINESTERASES
Y. Nicolet, F. Nachon, P. Masson, O. Lockridge, J-C. Fontecilla-Camps,
France |
| 15:25 |
INTRINSIC
TRYPTOPHAN FLUORESCENCE OF CHOLINESTERASES: DIRECT, NON-PERTURBING
MONITORING OF ENZYME-LIGAND INTERACTIONS
Z. Radic, E. Kim, P. Taylor, USA |
| 15:45 |
SURPRISING
FINDINGS FROM THE FUNCTIONAL ANALYSIS OF HUMAN ACETYLCHOLINESTERASE
ADDUCTS OF ALZHEIMER'S DISEASE DRUGS
A. Ordentlich, C. Kronman, D. Barak, N. Ariel, D. Kaplan,
B. Velan,
A. Shafferman, Israel |
| 16:05 |
UNFOLDING
AND FOLDING OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE
L. Weiner, C.B. Millard, I. Shin, E. Roth, D. Kreimer, I.
Silman, Israel |
| 16:25 |
Coffee Break and Poster
Viewing |
| 17:00 -18:20 |
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| SESSION 9 |
| Chairperson: |
P.Y. Masson, France |
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| 17:00 |
SCAVENGER
PROTECTION AGAINST ORGANOPHOSPHATES BY CHOLINESTERASES
B.P. Doctor, A. Saxena, M.T. Clark, Y. Rosenburg, D.M. Maxwell,
D.E. Lenz, Y. Ashani, USA, Israel |
| 17:20 |
A
COMPLEX ARRAY OF POST-TRANSLATION MODIFICATIONS DETERMINES THE CIRCULATORY
LONGEVITY OF ACETYLCHOLINESTERASE IN A HIERARCHIAL MANNER
C. Kronman, T. Chitlaru, A. Ordentlich, B. Velan, A. Shafferman,
Israel |
| 17:40 |
PRESYNAPTIC
INHIBITION OF CENTRAL ACETYLCHOLINE RELEASE WITH A1 LIGANDS: PREVENTION
OF CHOLINERGIC CRISIS
H.P.M. van Helden, T.J.H. Bueters, B. Groen, M. Danhof,
A.P. Ijzerman, The Netherlands |
| 18:00 |
POLYURETHANE
IMMOBILIZED ENZYMES: OP SENSING AND DECONTAMINATING MATRIXES
R.K. Gordon, B.P. Doctor, S.R. Feaster, A.T. Gunduz, E.D.
Clarkson,
D.E. Lenz, D.M. Maxwell, T. Cronin, J.P. Skvorak, M.C. Ross, USA |
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