SCIENTIFIC PROGRAM

MONDAY, OCTOBER 4, 1999

OPENING CEREMONY

08:30 OPENING

SESSION I
JOINT SYMPOSIUM, EACPT 3/JC4 AND EURO-DURG:
DRUG UTILIZATION IN QUALITY ASSESSMENT OF DRUG THERAPY

Co-Chairperson: J. Hasford, Germany

M. Bogaert, Belgium

09:30 DRUG RELATED HOSPITAL ADMISSIONS: THE ULTIMATE MEASURE FOR PRESCRIBING QUALITY
J. Hallas, Denmark

10:00 DRUG INTAKE OMISSIONS AND THEIR CONSEQUENCES
R. Vander Stichele, Belgium

10:30 COFFEE BREAK

11:00 VARIATIONS IN EVIDENCE BASED PRESCRIBING. IMPLICATIONS FOR DRUG UTILISATION RESEARCH
J. Ferguson, UK

11:30 EFFECTIVE INTERVENTIONS TO OPTIMIZE PRESCRIBING QUALITY
N.S. Freemantle, UK

12:00 THE USE OF PSYCHOACTIVE MEDICATIONS AND COGNITIVE FUNCTION IN THE OLDEST OLD
D. Orwig, C. Dellasega, USA, S. Berg, Sweden

SESSION II
GENE DELIVERY SYSTEMS

Co-Chairperson: R.J. Levy, USA

G. Golomb, Israel

09:30 DNA DELIVERY SYSTEMS FOR CARDIOVASCULAR GENE THERAPY
R.J. Levy, USA

10:00 TAILOR-MADE POLYMERIC GENE CARRIERS
S.W. Kim, USA

10:30 COFFEE BREAK

11:00 RECEPTOR DEPENDENT CELLULAR TARGETING OF GENE DELIVERY SYSTEMS
T.J.C. van Berkel, P.C.N. Rensen, L.A.M.J. Sliedregt, E.A.L. Biessen, The Netherlands

11:30 POLYMERIC CONTROLLED DELIVERY FOR GENE DELIVERY AND IMMUNOTHERAPY
K. Leong, K. Roy, H. Mao, V. Truong-Le, T. August, S. Huang, S. Walsh, USA

POSTER VIEWING AND DISCUSSION
A. DRUG UTILIZATION IN QUALITY ASSESSMENT OF DRUG THERAPY

Chairperson: K. Brune, Germany

THE ROLE OF HUMANITARIAN AID ON HOSPITAL USE OF ANTIBIOTICS: SOME EXPERIENCES FROM BOSNIA AND HERZEGOVINA
D. Babaic-Djuric, S. Stoisavljevic-Satara, N. Milosevic, R. Skrbic, Bosnia

WHAT PREDICT THE NUMBER OF DIFFERENT DRUGS PRESCRIBED IN GENERAL PRACTICE?
L. Bjerrum, U. Bergman, Denmark

A HPLC METHOD FOR DETERMINATION OF MIRTAZAPINE AND N-DESMETYLMIRTAZAPINE IN SERUM
H. Bjork, F. Bengtsson, Sweden

THE ATTITUDE OF PHYSICIANS AND WOMEN TO HORMONAL CONTRACEPTION IN SLOVAK REPUBLIC
S. Edelsteinova, P. Gibala, M. Kriska, Slovak Republic

PRIMARY CARE PRESCRIBING OF LIPID LOWERING DRUGS
J.J. Ferguson, J. Field, K. Frenz, UK

PHARMACOVIGILANCE OF THE "ESSENTIAL" ANTIBIOTICS IN BULGARIA
I. Getov, A. Doma, V. Petkova, Z. Dimitrova, Bulgaria

ANALYSIS OF NIMESULIDE (NIM) AND DICLOFENAC (DIC) PRESCRIPTIONS IN A SICILIAN (ITALY) OUTPATIENT COMMUNITY
S. Greco, V. Arcoraci, G. Mazzaglia, G. Cucinotta, A.P. Caputi, Italy

USING DRUG DATA BASES - THE DANISH WAY
B.D. Hansen, S. Gunnarsdottir, K. Schaefer, J. Kirkegaard, P. Ehlers, B. Toft, C.M. Ejlersen, K. Nielsen, P.O. Olsen, B.O. Larsen, A. Nissen, Denmark

PATIENT REPORTED COMPLIANCE IN GENERAL MEDICINE AND HIV INFECTED PATIENTS
M. Hennessy, M. Ryan, C. Merry, K. Sabra, F. Mulcahy, J. Feely, M. Barry, Ireland

PHARMACOTHERAPY OF PREVALENT ASTHMA IN THE UNITED STATES IN 1996
B. Huang, K.A. Bachmann, R. Chen, J. MacAllister, USA

ARE MOSTLY USED DRUGS IN THE FIRST TRIMESTER OF PREGNANCY SAFE AND ADEQUATE?
E. Janekova, Slovak Republic

ASTHMA PRESCRIPTION PATTERNS IN ESTONIA
R.A. Kiivet, L. Nirk, I. Kaur, Estonia

ANTIBIOTICS DRUG UTILIZATION IN KUPAT HOLIM CLALIT HOSPITALS IN ISRAEL 1995-1998
R. Kitzes-Cohen, A. Wasserman, A. Hanoch, N. Bar-Joseph, H. Magal, A. Goldscmid, Israel

USE OF DRUGS AT DISCHARGE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION IN THE GENERAL HOSPITAL ZADAR, CROATIA
A. Knezevic, Croatia

USE OF HORMONE REPLACEMENT THERAPY 1993-1998 IN THE COUNTY OF FUNEN, DENMARK. A PHARMACOEPIDEMIOLOGICAL INVESTIGATION OF UTILISATION AND COMPLIANCE
J. Larsen, J. Sondergaard, M. Andersen, Denmark

DRUG TREATMENT OF DEPRESSION IN ESTONIA
T. Marandi, L. Rago, Estonia

ESTABLISHMENT OF A DRUG UTILIZATION DATABASE IN ISRAEL
E. Marom, B. Haran, S. Shani, Israel

POSTER VIEWING AND DISCUSSION
A. DRUG UTILIZATION IN QUALITY ASSESSMENT OF DRUG THERAPY (cont)

Chairperson: K. Brune, Germany

 

USING PATTERN OF DIGOXIN IN ESTONIA AND BIOAVAILABILITY OF LOCAL MARKET LEADR
R. Pahkla, L. Rootslane, L. Rago, Estonia

PRESCRIPTION AND USAGE OF ESSENTIAL DRUGS – A COMPARATIVE ANALYSIS BETWEEN BULGARIA AND BOSNIA and HERZEGOVINA
G.I. Petrova, Bulgaria, T. Falkenberg, Sweden, T.V. Benisheva-Dimitrova, Bulgaria, D. Linari, Bosnia

MEASURING ASTHMA PRESCRIBING QUALITY IN GENERAL PRACTICE
L.G. Pont, C.C.M. Veninga, P. Denig, F.M. Haaijer-Ruskamp, The Netherlands

THE HOSPITAL CONSUMPTION OF CARDIOVASCULAR DRUGS DURING WAR AND POST-WAR PERIOD IN BOSNIA: THE ROLE OF HUMANITARIAN AID
R. Skrbic, S. Stolisavljevic-Satara, N. Milosevic, D. Babic-Djuric, B. Ilisic, Bosnia

THE COMPARED ANALYSIS OF THE CONSUMPTION OF THE ANTIMICROBIAL DRUGS IN  THE CENTRAL CLINICAL HOSPITAL RIJEKA AND THE CLINICAL HOSPITAL SPLIT
V. Rosovic-Bazijanac, V. Strahinja, M. Stipic-Rodin, Croatia

PRODUCTION AND DISSEMINATION OF INFORMATION FROM A NATIONAL DRUG INFORMATION CENTER TO PHYSICIANS AND PHARMACISTS USING STANDARD GENERALIZED MARKUP LANGUAGE AND THE NEW EUROPEAN STANDARD FOR MEDICINAL PRODUCT IDENTIFICATION
R.H. Vander Stichele, J. Van Campen, J. Proost, I. Latour, Belgium

EFFECTS OF SMOKING, CYP2D6 GENOTYPE AND CONCOMITANT DRUG INTAKE ON THE STEADY-STATE PLASMA CONCENTRATIONS OF HALOPERIDOL AND REDUCED HALOPERIDOL IN SCHIZOPHRENIC INPATIENTS
R.H. Vander Stichele, L. Pan, R.T. Rosseel, J.A. Berlo, N. De Schepper, F.M. Belpaire, Belgium

ASSESSMENT OF THE DRUG LEVEL IN LUNG TISSUE AND BRONCHIAL SECRETION WITH ORAL DRUG INTAKE OMISSION
E.M. Ouriemchi, J.M. Vergnaud, France

ASSESSMENT OF THE PLASMA DRUG LEVEL WITH ORAL DRUG INTAKE OMISSION
E.M. Ouriemchi, J.M. Vergnaud, France

ANTIBIOTIC UTILISATION AT THE UNIVERSITY HOSPITAL AFTER INTRODUCING AN ANTIBIOTIC POLICY
V. Vlahovic-Palcevski, M. Morovic, Croatia

FEATURES OF POLYPHARMACY WITHIN THE GENERAL MEDICAL SERVICES SCHEME IN IRELAND
D. Williams, A. Kelly, J. Feely, Ireland

POSTER VIEWING AND DISCUSSION
B. THERAPEUTIC DRUG MONITORING

 

EFFECTIVENESS OF DILTIAZEM LANNACHER RETARD FORM IN PATIENTS
WITH STABLE ANGINA ON EXERTION
Yu.B. Belousov

APPLICATION OF POPULATION MODELING TO MONITOR AND ADJUST ANTICONVULSANTS DOSAGE REGIMENS
Yu.B. Belousov, I.B. Bondareva, A.V. Sokolov, I.F. Tischenkova, Russia

DEVELOPMENT OF A FULLY AUTOMATIC METHOD OF ANALYSIS OF PAROXETINE IN BREASTMILK AS A PART OF A CLINICAL STUDY
Y.K. Bergsholm, M. Krogh, K. Rebasaet, I. Matheson, Norway

THERAPEUTIC DRUG MONITORING OF GENTAMICIN IN SERUM AND SALIVA OF CHILDREN: ONCE-DAILY AS COMPARED TO TWICE OR THRICE-DAILY
M Berkovitch, M Bulkowstein, R Silverman, Z Chen-Levy, R Greenberg, E Lahat, Israel

DETERMINATION OF PLASMA 1-HYDROXY-MIDAZOLAM CLUCURONIDE IN INTENSIVE CARE PATIENTS: RELATION WITH THE LEVEL OF SEDATION
M. Bolon, O. Bastien, R. Boulieu, France

URINARY COTININE ASSAYS: A NEED FOR INDIVIDUAL TRANSDERMAL NICOTINE THERAPY IN SMOKING CESSATIONS-A PILOT STUDY OF OVER 1000 PATIENTS
P. Bustany, B. Le Maitre, P. Cleren, France

CHANGES IN (R)- & (S)- WARFARIN AND VITAMIN K PLASMA
CONCENTRATIONS AND VARIABILITY IN ANTICOAGULATION WITH
WARFARIN
F. Kamali, C. Edwards, T. Butler, H.A. Wynne, UK

A MATRIX MODEL IN DESCRIBING AND IMPROVING ASTHMA TREATMENT
P. Lagerlov, M. Andrew, Norway

RISPERIDONE AND 9-OH-RISPERIDONE PLASMA LEVELS IN PSYCHIATRIC PATIENTS
A. LLerena, Spain, R. Berecz, Hungary, A. De-la-Rubia, M. Kellerman, M-J Norberto, M Martinez, I Degrell

DOES MONITORUNG  OF DIGOXIN LEVELS SERVE AS AN ESSENTIAL  TOOL IN OPTIMIZING THERAPY
H. Mayan, E. Bloom, A. Hoffman, Israel

PLASMA LEVELS OF 8-METHOXYPSORALEN AFTER BATH-PUVA THERAPY
U. Merkel, A. Balogh, U. Barta, U. Wollina, Germany

METHOD FOR ANALYSIS OF REBOXETINE AND ITS DE-ETHYLATED METABOLITE IN SERUM USING SOLID PHASE EXTRACTION AND HPLC
D. Ohman, B. Norlander, F. Bengtsson, C. Peterson, Sweden

SALIVA PARAXANTHINE / CAFFEINE RATIO IN PATIENTS WITH LIVER CIRRHOSIS
F. Perlik, T. Pucelikova, Czech Republic

SPECIFIC ANTIBODIES AS A  NEW MARKER OF CAPTOPRIL EFFICACY IN PATIENTS WITH ARTERIAL HYPERTENSION
V. Petrov, Yu. Lopatin, O. Ilyukhin, A. Yakovlev, Russia

A HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC (HPLC) ASSAY OF LAMOTRIGINE FOR PHARMACOKINETIC INVESTIGATIONS AND THERAPEUTIC DRUG MONITORING
M. Pokrajac, B. Brzakovic, B. Miljkovic, Yugoslavia

POSTER VIEWING AND DISCUSSION
B. THERAPEUTIC DRUG MONITORING (cont)

TDM-BASED POST MARKETING SURVEILLANCE OF THE ANTIDEPRESSANT CITALOPRAM IN ADOLESCENTS
M. Reis, F. Bengtsson, Sweden

INFLUENCE OF AGE, GENDER, SMOKER BEHAVIOUR AND CYP2D6 METABOLIC CAPACITY ON PLASMA LEVELS OF RISPERIDONE AND 9-HYDROXYRISPERIDONE
M.G. Scordo, G. Facciola, A. Avenoso, M.L. Dahl, E. Spina, Italy

RELATIONSHIP BETWEEN PLASMA CONCENTRATIONS OF CLOZAPINE AND NORCLOZAPHINE AND THERAPEUTIC RESPONSE IN PATIENTS WITH SCHIZOPHRENIA
E. Spina, A. Avenoso, G. Facciola, M.G. Scordo, E. Perucca, Italy

THERAPUETIC MONITORING OF BUSULFAN IN PRE-BONE MARROW TRANSPLANTATION TREATMENT AT THE RAMBAM MEDICAL CENTER
E. Hoffer, A Tabak, Y. Bentur, N. Krivoy, Israel

ASSESSMENT OF THE DRUG LEVEL IN THE PLASMA AND TISSUES FOR THERAPEUTIC DRUG MONITORING
E.M. Ouriemchi, J.M. Vergnaud, France

LAMOTRIGINE SERUM CONCENTRATIONS MONITORING IN CHILDREN WITH EPILEPSY
D. Vitezic, M. Tonkovic, E. Paucic Kirincic, A. Sasso, V. Vlahovic Palcevski, Croatia

RELATIONSHIP BETWEEN SALIVA AND PLASMA CONCENTRATIONS OF PHENYLPROPANOLAMINE, DEXTROMETHORPHAN AND DEXTRORPHAN IN HUMAN SUBJECTS
T. Zimmermann, H. Laufen, A. Lammerich, R.A. Yeates, K.-D. Riedel, F. Scharpf, Germany

POSTER VIEWING AND DISCUSSION
C. ADVANCES IN THE USE OF VESICULAR CARRIERS FOR DRUG DELIVERY

LIDOCAINE - LOADED SURFACTANT VESICLES : CHARACTERIZATION AND RELEASE EXPERIMENTS
M. Carafa, E. Santucci, Italy, N. Dayan, E. Touitou, Israel

SELECTIVE3 MACROPHAGE-DEPLETION BY INTRACELLULAR DELIVERY OF CLODRONATE SUPRESSES NEOINTIMAL FORMATION FOLLOWING BALLOON CARTOID INJURY IN RATS
H.D. Danenberg, I. Fishbein, G. Amir, N. Ron, I. Gatti, J. Monkkonen, G. Golomb, Israel

TRANSDERMAL DELIVERY OF POLYPEPTIDES
I. Dkeidek, E. Touitou, Israel

BUTYRILOCHOLINE ESTERASE CARRYING LIPOSOMES: PHYSICOCHEMICAL AND BIOCHEMICAL PROPERTIES
S.. Fischer, A. Arad, R. Margalit, Israel

NOVEL VESICULAR CARRIER FOR CELLULAR, DERMAL, AND TRANSDERMAL DELIVERY
E. Touitou, B. Godin, N. Dayan, S. Pisanty, E. Horowitz, M. Eliaz, Israel

QUALITATIVE AND QUANTITATIVE DETECTION OF BIOADHESIVE LIPOSOMES DESIGNATED FOR OCULAR THERAPIES
D. Peer, R. Margalit, Israel

LIPOSOME FORMULATED BUTYRYLCHOLINE ESTERASE: ANALYTICAL AND BIOCHEMICAL ASSESSMENT
I. Schumacher, A. Arad, R. Margalit, Israel

EFFECT OF PERMEATION ENHANCERS ON EPIDERMAL LANGERHANS CELLS: A MORPHOLOGICAL STUDY BY COMPUTERIZED IMAGE ANALYSIS
J. Karl, S. Buinover, Y. Becker, E. Touitou, Israel

1 LUNCH BREAK

SESSION III
THERAPEUTIC DRUG MONITORING

Co-Chairperson: F.G.F. Sjoqvist, Sweden

E. Zylber-Katz, Israel

14:30 THE ROLE OF CLINICAL PHARMACOLOGISTS IN TDM
L.F. Gram, Denmark

15:00 TDM OF CANCER CHEMOTHERAPY
J.H.M. Schellens, The Netherlands

15:30 COFFEE BREAK

16:00 TDM AND NEW ANTIDEPRESSANTS
F. Bengtsson, Sweden

16:30 THERAPEUTIC DRUG (TDM) MONITORING OF ANTIRETROVIRALS IN HIV-POSITIVE PATIENTS
D.J. Back, S.H. Khoo, UK, C. Merry, M.G. Barry, Ireland

SESSION IV
ADVANCES IN THE USE OF VESICULAR CARRIERS FOR DRUG DELIVERY

Co-Chairperson: D.J.A. Crommelin, The Netherlands

E. Touitou, Israel

14:30 LIPOSOMES FOR TARGETED DELIVERY OF PEPTIDES AND PROTEINS
D.J.A. Crommelin, The Netherlands

15:00 LIPOSOMES FOR PULMONARY ADMINISTRATION
H. Schrier, G. Hochhaus, R. Gonzalez-Rothi, F.L. Sorgi, I. Gonda, USA

15:30 COFFEE BREAK

16:00 IMPROVED DERMAL DELIVERY WITH ETHOSOMAL CARRRIERS
E. Touitou, Israel

16:30 THE CHALLENGE OF DEVELOPING EFFICACIOUS LIPOSOME-BASED DRUG DELIVERY PRODUCTS: FROM BASIC RESEARCH TO APPROVED DRUGS
Y. Barenholz, Israel