2. The Insulinomimetic Effects of Metal Ions: Potential Therapy for Diabetes Mellitus

September 14-15, 2000

Thursday, September 14, 2000
Session I: The molecular mechanisms of action of ion metals
15:00-15:15  Introduction: General presentation on ion-metals as antidiabetic agents
J.H. McNeill, Canada
15:15-15:45 Peroxovanadium compounds: Potent phosphatase inhibitors with insulin-like effects
B.I. Posner, Canada
15:45-16:15  PI-3 kinase and the insulin-like effect of vanadate
J.M. Carrascosa, Spain
16:15-16:45 Coffee Break and Poster Session
16:45-17:15 The role of PKB in insulinomimesis by vanadium compounds.
A.K. Srivastava, Canada
Friday, September 15, 2000
Session II: The insulinomimetic and antidiabetic effects of metal ions
09:00-09:30 The effect of vanadium on GLUT4 translocation in skeletal muscle
I.G.Fantus, Canada
09:30-10:00  The effect of selenium on glucose tolerance in STZ-diabetic rats
J.H. McNeill, Canada
10.00-10:30  The effect of vanadium on insulin secretion in diabetic rats
G.H. Cros, France
10:30-11:00 Coffee Break and Poster Session
11:00-11:30 The pharmacokinetic of vanadyl sulfate and its effect in the treatment of type 2 human diabetes
J.L.Chiasson, Canada
11:30-12:15 Poster discussion
12:15-14:00  Lunch Break and poster session
Session III: The antidiabetic effect of tungstate
14:00-14:30 The effects of tungstate on beta cells
R. Gomis, Spain
14:30-15:00 Effects of tungstate on insulin secretion in the perfused rat pancreas
J. Marco, Spain
15:00-15:30  Regulation of islet cell neogenesis by tungstate
J.J. Gagliardino, Argentina
15:30-16:00  Coffee Break and Poster Session
16:00-16:30  The effects of tungstate on liver and muscle
J.J. Guinovart, Spain
16:30-17:00 Comparative cell toxicity between vanadate and tungstate derivatives
J. Domingo, Spain
17:00 Conclusion Remarks
R.Gomis, Spain


Hotel Calipolis, Passeig Maritim s/n, Sitges, Barcelona, Spain

Jean-Louis Chiasson, Canada


Bayer, Spain

FOR GENERAL, REGISTRATION AND ABSTRACT ENQUIRIES
Ramon Gomis
Hospital Cl?nic i Universitari
Servei Endocrinologia i Diabetis
Villarroel, 170
08036 Barcelona, SPAIN
Tel: +34 93 2275411
Fax: +34 93 4516638
E-mail: gomis@clinic.ub.es