ÿþ<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd"> <html> <head> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1"> <title>EASL 2010 - Poster Presentations</title> <link rel="stylesheet" type="text/css" href="style.css"> </head> <body> <table width="750" align="center" border="0" cellspacing="0" cellpadding="0" class="MainTable"> <tr> <td><img src="http://www2.kenes.com/liver-congress/PublishingImages/top_ei.jpg" width="760" height="129" /></td> </tr> <tr> <td class="content"><h1>Poster Presentations</h1> <P><b>Session Title:</b> Category 8b. ALCOHOLIC DRUG-INDUCED AND FATTY LIVER DISEASE: b. DILI AND ACLOHOLIC LIVER DISEASE<br><b>Presentation Date:</b> Apr 17, 2010</P><h2 align='left'><B>IS TRUTH SURVIVAL IN HEPATOLOGY ASSOCIATED WITH HIRSCH INDEX (H)?</B></h2> <p align='left'><b>T. Poynard</b><sup>1</sup>*, M. Munteanu<sup>2</sup>, V. Ratziu<sup>1</sup>, Y. Benhamou<sup>1</sup>, D. Thabut<sup>1</sup>, O. Deckmyn<sup>2</sup><br> <em><sup>1</sup>UPMC APHP Paris Liver Center, <sup>2</sup>Biopredictive, Paris, France. *thierry@poynard.com</em></p><br> <p align='justify'><b><b>Aim: </b> </b>Factors associated with the survival of truth of clinical conclusions in the medical literature are unknown. We hypothesized that publications from a first author with a higher h (h=number of publications "h" cited at least h times in the literature), which quantify an individual´s scientific research output, should have longer half-live. <br> <b><b>Methods: </b> </b>We used 472 original articles concerning cirrhosis or hepatitis published from 1945 to 1999. with an identified first author, previously assessed (Annals Internal Medicine 2002). The survival of the main conclusions have been updated in 2009. h was computed using Google scholar, Scopus, and an home made algorithm (HepaTop) to reduce false positive/negative rates combining Medline and hand searching. By definition h is highly related to the authors´age. Truth survival (percentage of studies not being false or obsolete) was assessed by Kaplan Meier method (stratified by median date of publication) and Cox model including factors (design, journal, methods) associated with h or conclusions´ survival.<br> <b><b>Results: </b> </b>In 2009, 282 out of 472 conclusions (60%) were still considered true, 91 were obsolete (19%) and 99 (21 %) false. The half-life of truth was 55 years. The median h of first author was 24 (range 1-85). Authors with true conclusions had significantly higher h (median h=28) than those with obsolete (h=19; P=0.002) or false conclusion (h=19; P=0.01). Factors associated with h were publications after 1980 (h=26 vs 14; P< 0.0001), methodological quality (h=36 vs 20; P< 0.0001), and therapeutic (h=25) or diagnostic (h=26) versus cognitive studies (h=20; P=0.003). <br> Before 1980, the 50 year survival of conclusions derived from authors with h>24 (n=88) was 62±6% (m±SE) vs 65±6% in those (n=141) with h< 24 (P=0.31). After 1980, the 30 year survival of conclusions derived from authors with h>24 (n=144) was 50±7% vs 29±9% for those with h< =24 (n=99; P=0.13). Using multivariate analysis, three factors were associated with true conclusions survival (odds ratio; P significance): methodological quality (3.21; P< 0.0001), negative conclusions (1.43; P=0.008), and h>24 (1.35; P=0.02).<br> <b><b>Conclusions: </b> </b>In Hepatology the scientific output of authors (h-index) is positively associated with the methodological quality and the survival of their studies´ conclusions.</p> <br><a href='Session-P03-8b.htm'>Back</a><br> <p>&nbsp;</p> <p>&nbsp;</p></td> </tr> </table> </body> </html>