ÿþ<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd"> <html> <head> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1"> <title>EASL 2010 - Poster Presentations</title> <link rel="stylesheet" type="text/css" href="style.css"> </head> <body> <table width="750" align="center" border="0" cellspacing="0" cellpadding="0" class="MainTable"> <tr> <td><img src="http://www2.kenes.com/liver-congress/PublishingImages/top_ei.jpg" width="760" height="129" /></td> </tr> <tr> <td class="content"><h1>Poster Presentations</h1> <P><b>Session Title:</b> Category 5g. VIRAL HEPATITIS: g. HEPATITIS C - CLINICAL (THERAPY)<br><b>Presentation Date:</b> Apr 15, 2010</P><h2 align='left'><B>SUSTAINED VIROLOGICAL RESPONSE (SVR) ACCORDING THE TYPE OF EARLY VIROLOGICAL RESPONSE (EVR) AND OTHER PROGNOSTIC FACTORS IN MONOINFECTED HCV AND COINFECTED HCV/HIV GENOTYPE 1 PATIENTS</B></h2> <p align='left'><b>P.R.L.d. Almeida</b><sup>1</sup>*, A.A.D. Mattos<sup>2</sup>, C.V. Tovo<sup>3</sup><br> <em><sup>1</sup>Internal Medicine, Hospital Nossa Senhora da Conceição, <sup>2</sup>Gastroenterology, Santa Casa de Porto Alegre, <sup>3</sup>Hospital Nossa Senhora da Conceição, Post-Graduation Course of UFCSPA, Porto Alegre, Brazil. *paulorlalmeida@terra.com.br</em></p><br> <p align='justify'><b>Background: </b> Some factors to predict the SVR are the genotype and the fibrosis grade, although there are others to be considered, mainly in coinfected patients HCV/HIV.<br><b>Objectives: </b> Evaluate different prognostic factors to obtain SVR in HCV and HCV/HIV genotype 1.<br><b>Methods: </b> Cohort study, retrospective, where the registers of patients monoinfected HCV or coinfected HCV/HIV, genotype 1 treated with peguilated interferon (PEG) + ribavirin (RBV) 48 weeks were reviewed. The prognostic factors viral load greater than 600,000UI/ml, age > 40 years and fibrosis grade were evaluated pre-treatment, and also the EVR considering the reduction of 2 logs or negative PCR in the week 12. Treatment was PEG alpha-2a 180 mcg or alpha-2b at a dose of 1.5 mcg/kg, once a week associated with RBV 1,000 mg/day for patients with less than 75 Kg or 1,250 mg/day for patients with 75 Kg or more, during 48 weeks. For statistical analysis, multivariated analysis was used. The significance level adopted was 5%.<br><b>Results: </b> There were 323 monoinfected HCV and 59 coinfected HCV/HIV. <br><br><br><table border=1> <tr><td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>viral load</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>fibrosis grade</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>age</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><2 LOG RVS (%)</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>PCR (-) RVS (%)</span></td> </tr><tr><td width='20%' align='left'> </td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>F1+F2</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><40 >40</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>25.5 17.0</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>79.7 70.0</span></td> </tr><tr><td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><600,000 UI/ml</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>F3</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><40 >40</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>17.3 11.1</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>70.5 58.8</span></td> </tr><tr><td width='20%' align='left'> </td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>F4</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><40 >40</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>8.6 5.3</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>52.0 39.3</span></td> </tr><tr><td width='20%' align='left'> </td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>F1++F2</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><40 >40</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>19.4 12.6</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>73.4 62.2</span></td> </tr><tr><td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>>600,000 UI/ml</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>F3</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><40 >40</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>12.8 8.1</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>62.7 50.1</span></td> </tr><tr><td width='20%' align='left'> </td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>F4</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><40 >40</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>6.2 3.8</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>43.2 31.3</span></td> </tr></table><i>[Monoinfected HCV]</i><br /><br><br><table border=1> <tr><td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>viral load</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>fibrosis grade</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>age</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>< 2logs RVS (%)</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>PCR (-) RVS (%)</span></td> </tr><tr><td width='20%' align='left'> </td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>F1+F2</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><40 >40</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>14.1 8.9</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>65.3 52.9</span></td> </tr><tr><td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><6000,000 UI/ml</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>F3</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><40 >40</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>9.1 5.6</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>53.4 40.6</span></td> </tr><tr><td width='20%' align='left'> </td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>F4</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><40 >40</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>4.3 2.6</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>34.1 23.6</span></td> </tr><tr><td width='20%' align='left'> </td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>F1+F2</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><40 >40</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>10.3 6.4</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>56.0 44.1</span></td> </tr><tr><td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>>6000,000UI/ml</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>F3</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><40 >40</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>6.6 4.0</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>44.6 32.5</span></td> </tr><tr><td width='20%' align='left'> </td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>F4</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'><40 >40</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>3.1 1.9</span></td> <td width='20%' align='left'><span style='font-weight:normal; font-style:normal'>26.7 17.9</span></td> </tr></table><i>[coinfected HIV/HCV]</i><br /><br><b>Conclusions: </b> Patients with cirrhosis HCV genotype 1, high viral load, >40 years, coinfected with HIV or not, will present a very low SVR if did not obtain negative PCR in week 12 of treatment, and should be evaluated for discontinuation.<br></p> <br><a href='Session-P01-5g.htm'>Back</a><br> <p>&nbsp;</p> <p>&nbsp;</p></td> </tr> </table> </body> </html>