THE EFFECT OF
BRIMONIDINE IN EARLY POSTOPERATIVE HYERTONY FOLLOWING PHACOEMULCIFICATION
Kandarakis A., Bartsi E., Tomais G., Voutsinas P., Vrionis G., Lenas A.
and Orfanidis T.
Purpose: To assess the efficacy of Brimonidine in early postoperative
hypertony after phacoemulcification.
Methods: Forty-eight normal eyes, with cataract and
IOP < 21mmHg, from 48 patients participated in that prospective study.
Following surgery all patients were randomly divided in two groups A and B,
with 27 and 21 patients espectively. At the end of surgery, 1 drop of
Brimonidine 0.2% was instilled in all patients of group A, and 1 drop of BSS
was instilled in all patients of group B.IOP was measured at 6th and 18th hours
postoperatively.
Results: The mean preoperative IOP was 13.68(± 2.32) mmHg in-group A and
14.38(± 3.32) mmHg in-group B (p=0.42). The mean postoperative IOP at 6th hour
was 19.35(± 6.34) mmHg in group A and 24.31(± 7.47) mmHg in group B (p=0.019),
while at 18th hour was 15.31(± 4.83) mmHg in group A and 15.9(± 5.82) mmHg in
group B (p=0.71). IOP>21mmHg at 6th and 18th postoperative hour was found in
14.8% and 11.11% in group A, as well as 66.66% and 19.0% in group B
respectively.
Conclusions: Brimonidine reduces significantly hypertony at 6th
postoperative hour. There is also a very significant difference between the
number of patients who developed IOP>21mmHg in the two groups at 6th
postoperative hour (p<0.0001).