Purpose: to evaluate the diagnostic accuracy of ibopamine test
Methods: we selected 218 glaucomatous patients (group 1) and 210 normal subjects (group 2). Among
the second group 64 subject (subgroup 2b) were previously studied and selected
according to very restricted inclusion criteria to ensure the lack of any sign of
hydrodynamic disorders. All the subjects underwent to Ibopamine test (IOP
changes 45 min after topically administered 2% Ibopamine). ROC curve was
calculated to establish the cut-off value to consider the test positive or negative. Sensitivity
and specificity of the test were calculated and presented with 95% confidence
intervals.
Results: According to ROC curve, the cut-off value to consider positive
or negative the test was set to >3 mmHg. Sensitivity = 85.7% (95%CI:
82-89%); Specificity =94.3% (95%CI: 91.9-96.6%). Considering only subgroup 2b,
specificity was increased to 100% (95%CI: 98-100%).
Conclusion: Ibopamine is a valuable, simple and low-cost test that can
be successfully used in glaucoma diagnostics as a tool for detecting functional
alteration of outflow pathways