The activation of lipid peroxydation (LPO) is a general factor in many
cases of pathogenic damage and it plays a major role in the development of many
ophthalmologic diseases; such as glaucoma, cataract and different genesis of
retinopathies. That’s why the stabilizing of the intensive processes is an up –
to date problem in ophthalmology.
Known as vitamin Bx, para- aminobenzoicacid (PABA) is both a
biologically active substance and, can be effective as an antioxidant.During
these investigations PABA was studied in the retina of Wistar type of rats at hypoxia
and a synthetic antioxidant was compared to emoxipin.
Materials & Methods
Afterwards, the pathological effect PABA was injected in to the
parabulbar. The rats were injected with 0,2-0,3ml and 0,007; 0,01; 0,02; 0,04;
0,06; and 0,08% of PABA and 0,01; 0,02 and 1% emoxipin. 1,3,6,11 hours later,
it was studied.
Results & Discussions
During the first hours after the induction of hypoxia the level of MDA
increased to 70-108%, after introducing 0,007% PABA in an hour the MDA level
reduced to 43-48%; 0,04 0,06 and 0,08% of PABA and 1-% emoxipin and the
comparison of the effect were carried out 2 and 12 hours later.
Conclusion
1. After the hypoxic affect PABA stabilizes the processes of LPO (by
decreasing the level of MDA) and has a protective effect on the retina.
2. Optimal dosage of PABA as an antioxidant for the retina is 0,04% and
it is equivalent to 1 % of emoxipin.