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Objective: To report the clinical and
histopathologic findings in one case of glaucoma associated with FAP type I .
Methods: Retrospective review of clinical findings
and course of one patient with available biopsy material from iris and
trabecular meshwork.
Measures: Intraocular pressure and visual field
changes during medical and laser therapy, and final surgical outcome.
Results: A 52 year-old white woman suffering from
FAP type I with recurrent right palpebral hematomas and anisocoria developed
unilateral glaucoma that was poorly responsive to medical therapy and laser
trabeculoplasty. IOP control was achieved after trabeculectomy using
mitomycin-c. Histopathologic analysis of the iris and trabecular meshwork
demonstrated amyloid deposit, suggesting outflow blockade as the possible
mechanism of glaucoma.
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