Purpose: To compare the IOP and hemodynamic effects of Dorzolamide and Latanaprost in normal tension glaucoma subjects. Methods: Twenty one normal tension glaucoma patients were washed out of all ocular medications (4weeks) then randomized into two groups; 11 receiving Trusopt TID, and 10 receiving Latanaprost once daily. Baseline measurements were obtained immediately after washout, and measurements were repeated after four weeks on drug, including heart rate, blood pressure, Goldmann IOP, color Doppler imaging (CDI) of the ophthalmic (OA), central retinal (CRA), temporal and nasal posterior ciliary arteries, and fluorescein scanning laser ophthalmoscopy angiography. Treatment and baseline measurements were compared by paired student's t-test. Comparison between groups was made by unpaired t-test. Results: Neither drug significantly affected any CDI parameter, however, the OA resistive index (RI) response to treatment was significantly different between drugs (p=0.0347); where Trusopt tended to reduce OA RI, and Xalatan tended to increase OA RI. Only Dorzolamide significantly hastened arteriovenous passage times
(p=0.0089). Conclusions: Only Dorzolamide significantly improves retinal hemodynamics. OA response to Dorzolamide and Latanaprost is significantly different.