Purpose:
To conduct the comparative study of AZOPT and TRUSOPT influence on IOP.
Methods:
The research was conducted with the participation of 20 patients with POAG and
20 healthy volunteers. Patients were distributed into 4 groups, depending on
the used drugs, by 10 persons in each. The IOP was measured in all patients
before treatment and in 1, 2 and 24 hours after instillation of medicine (AZOPT
or TRUSOPT).
Results:
The maximum reduction of IOP of
3,9 mmHg was measured in a group of healthy volunteers using TRUSOPT, and IOP
has decreased to 1,7 mmHg in the other group of voluntaries using AZOPT. In the
patients with POAG using TRUSOPT the average IOP reduced to 6,5 mmHg, and the
IOP reduction to 6,9 mmHg was observed in group of the patients with POAG using
AZOPT.
Discussion:
As the result of conducted study the hypotensive effect of both of a carbonic
anhydrase inhibitors was established in both groups of healthy voluntarees
and patients with POAG. TRUSOPT
and AZOPT have an approximately equal hypotensive effect in glaucoma patients.