Introduction: On the recent decades the
problem of early diagnostics and appropriate treatment of primary open-angle
glaucoma requires detailed research in clinical ophthalmology. According to the results of previous
studies IOP is characterized by expressed circadian periodicity, but the
precise characteristics of its chrono-organization in case of various pathologic
stages are not quite well defined.
Aim: The description of IOP
rhythm in Norma and pathology with evaluation of differences in IOP
chrono-organization in case of several clinical groups.
Materials
and Methods:
119 patients (183 eyes) were observed. They were divided into 3 clinical
groups: control group (normal IOP); glaucoma suspected group; glaucoma III-IV
st. group. Each group included the equal quantity of males/females (50-70
years) without accompanying pathology. Each eye never received any surgical
treatment.
IOP was measured with 6-hour interval
during 2 days with 3 hours-shifting (2nd day) employing standard
methodics. The obtained results were processed using cosinor-analysis and
statistically approved (t- quotient).
Results: We evaluated and described
the parameters of IOP circadian chronorhythm in control group patients (mesor
18-25 mm. Hg., IOP peak- 11.00 a.m., 8.00 p.m., sinusoidal rhythm). According
to obtained data in case of abovementioned groups we developed criteria scheme
for differentiation of normal and pathologic IOP rhythm. Suspicious glaucoma
group was characterized by 25% mesor increasing, shifting of IOP peaks to 8.00
a.m. and 5.00 p.m., new highest peak at 11.00 p.m. makes the rhythm ascending
one. Glaucoma patients rhythm reflected: IOP increase during 8.00a.m.-2.00 p.m.
period on the background of high mesor and amplitude fluctuations and
possessed descending
character.
Conclusions:
1.
Each clinical group has its own pathognomic sign IOP rhythm.
2.
These signs are recommended for adequate distribution of patients into
different diagnostic clinical groups.
3. We suppose the new time
periods for appropriate IOP-deviations diagnostics and adequate treatment of
primary open-angle glaucoma.