The purpose: The study of efficiency of application
brinzolamide at treatment of the patients with primary open-angle glaucoma.
Materials and methods: We observed 35 patients (57 eyes) with decompensated primary open-angel glaucoma. The measurement of
IOP was made 1, 2 and 24 hours
after single drop instillation of brinzolamide, and also weekly during three
month researches at application of brinzolamide 2 times per day.
Results and discussion:
The initial level of IOP was
26,17±2,6 mmHg. After a hour the
IOP decreased by 19,79 %, after 2 hours by 26,78 %, after 24 hours by 15,41 %
from an initial level of IOP. Brinzolamide was applicated during 12 weeks 2 times per day. The decrease of IOP was approximately identical and was
26,62 % over initial level.
The side-effects were
observed at 6 (15 %) patients. The burning and foreign body sensation, within
5-10 minutes after instillation, were most frequent (12,5%) among topical
side-effects. At one patient we received fibrinozno-plastic iridocyclitis after
single instillation of brinzolamide. Iridocyclitis was cured after 4 days of
standard therapy.
Conclusions: This investigation has shown, that brinzolamide
has marked hypotensive effect. Its
application 2 times per day allows to control IOP.