PURPOSE: The iris vasculature shows typical changes in Pseudoexfoliation Syndrome (PXS) revealed by iris fluorescein angiography (IFA), such as hypoperfusion, microneovascularisation, and anastomotic vessels. Iris indocyanine green angiography (IICGA) can visualize more precisely details of the iris vascular pattern, especially as regards hypoperfusion and capillary dilatations.
The aim of the study is to describe the angiographic features of PXS on IFA and IICGA, comparing eyes affected by capsular glaucoma with those not affected.
METHODS:
42 patients affected by PXS underwent a complete ophthalmologic examination
including IFA and IICGA. Thirty-two eyes were affected by capsular glaucoma.
IICGA was performed using IMAGEnet System H1024.
RESULTS: IFA can easily detect the
microneovascularisation, whereas IICGA allows a better recognition of iris
hypoperfusion and anastomotic vessels, and it can reveal iris pigment
epithelium defects. While the degree of
hypoperfusion was similar in the two subgroups, eyes affected by capsular
glaucoma showed more frequently signs of both microneovascularisation (marked
stromal tufts and marked plexi), and anastomotic vessels (peripheral loop,
lesser circle and oblique vessels), with statistically significant difference.
A clear correlation between hypoperfusion, microneovascularisation, and
anastomotic vessels as regards site and extent was not noticed.
CONCLUSIONS: A different
angiographic pattern can be detected in PXS eyes with capsular glaucoma in
comparison with eyes without it. Further studies are needed to correlate
angiographic features revealed by IFA and IICGA, with clinical features.