Purpose: to investigate the using of Proxophelini
(fixed combination of β1,2 α1 adrenoblocker Proxodololi 1
% and α1 agonist Clophelini hydrochloridi 0,25 %) by patients with
primary open angle glaucoma (POAG) with normal or high blood pressure, also if
there is tachiphylaxia to treatment with timololi 0,25 % and Pilocarpini
hydrochloridi 1 % twice a daily.
Methods: 30 patients with POAG, who were treated
with Timololi and Pilocarpini and had IOP > 22 mm. Hg., received
Proxophelini twice a daily, were tested for intraocular pressure (IOP), outflow
facility, visual field. Visual field testing had been done by computerized,
automated perimetry.
Results: During the treatment with Proxophelini IOP
were 16,3, 15,9 and 16,1 mm. Hg. after 3, 6 and 12 months, respectively, by 85
%, 75 % and 70 % patients. Outflow facility increased by 33 % in comparison to
Timolol with Pilocarpin.
Automated,
computerized perimetry showed the decrease of visual field defects in
comparison to Timolol and Pilocarpin.
Blood pressure and
pulse during the treatment with Proxophelini were statistically significant not
change.
Conclusions: Glaucoma patients prefer the treatment with
Proxophelin, because the quality of glaucoma patient's life is in general good,
when they are treated without miotic agents.