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ABSTRACT
TOPICS
A. BASIC ASPECTS OF GnRH ANALOGUES (AGONISTS AND ANTAGONISTS)
- Glycoprotein regulation in the gonadotrophs
- Design, synthesis and clinical pharmacology of effective and safe
antagonists of GnRH
- Developments of GnRH antagonists and update
- Primate studies on GnRH antagonists
- Clinical studies with GnRH antagonists
- GnRH analogues of the future
- Intracellular LH releasing mechanism by GnRH analogues
- Integrating signalling and “System Biology”
- GnRH receptor and signal transduction in normal and malignant tissues:
(normal pituitary, normal gonads, normal breasts, Myoma, Prostate Cancer,
ovarian, endometrial, Breast Cancer)
- GnRH receptor ligand interactions and signaling
- Direct effects of antagonists on granulosa cells
- Comparison of GnRH agonists and antagonists in experimental animal
models
- Controlled suppression of gonadal steroids with GnRH agonists
or antagonists
- Mechanism(s) of local effects of GnRH analogues and GnRH like-peptides
and their possible application in clinical practice
- Differences of GnRH analogues - fact or fiction
- Central and peripheral effects of different analogues
- Clinical impact of different analogues due to their chemical nature and
delivery system
- New indications for the use of GnRH analogues
- Pharmacokinetic characteristics of GnRH antagonist
- Pharmacodynamics of GnRH analogues (agonists and antagonists)
- Bio-Pharmaceutical studies (agonists and antagonists)
- Regulation of GnRH expression in intact and cancerous tissues
B. GnRH ANALOGUES IN BENIGN
AND MALIGNANT UROLOGICAL INDICATIONS
-
Mode of application of GnRH-agonists for the treatment of benign and
malignant diseases of the prostate
- Scopes and limits of endocrine management of BPH
- Combination of endocrine and non-endocrine treatment of BPH
- Scopes and limits of endocrine management of Prostatic Cancer
- Combination of endocrine and non-endocrine treatment of Prostate Cancer
- Neo and adjuvant treatment of LHRH analogues in early Prostate Cancer
- Combination therapy of LHRH analogues with chemotherapy in hormone
refractory PCA
- Intermittent therapy for Prostate Cancer
- Total versus partial androgen blockade in advanced Prostate Cancer
- Results of treatment of Metastatic Cancer using GnRH analogues
- Development of LHRH antagonists in Prostate Cancer
- Conservative management of benign prostate hypertrophy: future aspects
- New perspectives in the treatment of Prostate Cancer
- Treatment of hormone-refractory Prostate Cancer
- Epidemiology
- Scopes and limits of endocrine management of Prostate Cancer
C. GONADOTROPINS AND GnRH ANALOGUES IN
REPRODUCTION
- Modern concepts in ovarian stimulation
- Lessons learned from national and international registries
- The era of recombinant Gonadotropin
- Future Gonadotropin drugs
- Pharmacoeconomics as it pertains to the use of gonadotropins, GnRH
agonists and GnRH antagonists
- Mechanisms of actions and perspectives of the use of GnRH antagonists
in women
- Clinical application of GnRH analogues in reproduction
- The use of GnRH antagonists in conjunction with oral contraceptives in
ovarian stimulation protocols
- Use of GnRH analogues in the overall management of
polycystic ovarian disease
- Do GnRH analogues represent an effective adjunctive treatment of infertility
in polycystic ovarian disease?
- Use of GnRH analogues for in-vitro fertilization
- Will GnRH analogues help in diagnosis prevention and treatment
of functional ovarian cysts?
- Will application of GnRH analogues enable classifi cation of stages and
treatment of some types of premature ovarian failure?
- Results of GnRH antagonists in IVF
- Results of Dose-fi nding of GnRH antagonists
- Studies of multiple dose protocols of GnRH antagonists
- Optimization of GnRH antagonists protocol
- Studies of single dose protocols of GnRH antagonists
- Use of GnRH agonists for triggering ovulation in GnRH antagonists
protocols
- Minimization of OHSS in GnRH antagonist protocols
- Preservation of ovarian function and fertility in survivors
of gonadotoxic chemotherapy
- Results and follow-up of children born after GnRH antagonist therapy
D. GnRH ANALOGUES IN BENIGN GYNECOLOGICAL DISEASES
- Is there a role for GnRH antagonists in the management of endometriosis
- Long-term results with GnRH analogues in the treatment of endometriosis
- Early treatment of GnRH analogues in the treatment of endometriosis
- GnRH analogues in the management of pelvic pain
- The continuous benefi t of GnRH analogues in the conservative treatment
of genital endometriosis
- Management of active and inactive endometriosis
- Effects of GnRH antagonist on uterine leiomyoma growth and apoptosis
- The clinical value of long acting GnRH analogues
(agonists and antagonists), in the treatment of uterine fi broids
- The use of GnRH analogues for dysfunctional uterine bleeding
- Adverse effects of LHRH on mineral density: possible therapies
- The use of GnRH agonists and antagonists in the management
of Ovarian Cancer
- The use of GnRH agonists and antagonists in the management
of Breast Cancer
- The application of GnRH analogues in the management
of Endometrial Cancer
- The use of GnRH agonists and antagonists in the management
of other cancers
- The combined use of GnRH analogues and somatostatin in the
management of cancer
- The combination use of GnRH analogues and other therapeutic measures
in the management of cancer
- The potential diagnostic application of GnRH antagonists in
mammography
E. GnRH ANALOGUES IN CONTRACEPTION
- Animal models for testing GnRH analogues in female reproduction
- Peptide contraception by inhibition of ovulation using GnRH analogues
- Animal models for testing GnRH analogues in male reproduction
- The use of GnRH analogues in male contraception H
F. SAFETY
- Long term safety of GnRh analogues in the management of Prostate
Cancer
- Bone density changes associated with GnRH analogues
- Management of post-marketing surveillance following short and long-term
use of GnRH analogues
- Recovery of hormone secretion following long-term GnRH analogue
treatment
- The long-term effect on fertility and bone mass following chronic long
lasting GnRH analogues treatment in children
- Safety of short and long-term treatment with GnRH analogues
- Safety of GnRH antagonists for mother and child
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