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A. Basic Aspects of GnRH Analogues (Agonists and Antagonists)
- Glycoprotein regulation in the gonadotrophs
- Design, Synthesis and Clinical Pharmacology of effective and safe antagonists
of GnRH
- Developments of GnRH antagonists and update
- Primate studies on GnRH antagonists
- Clinical studies with GnRH antagonists
- GnRH analogues of the future
- Intracellular LH releasing mechanism by GnRH analogues
- Integrating signalling and "System Biology"
- GnRH receptor and signal transduction in normal and malignant tissues:
(Normal Pituitary,
- Normal Gonads, Normal Breast, Myoma, Prostate Cancer, Ovarian, Endometrial,
Breast Cancer)
- Effects of GnRH antagonists on spermatogenesis
- Direct Effects of antagonists on Granulosa cells
- Comparison of GnRH agonists and antagonists in experimental animal models
- Controlled suppression of gonadal steroids with GnRH agonists or antagonists
- Mechanism(s) of local effects of GnRH analogues and GnRH likepeptides
and their possible application
- in clinical practice
- Differences of GnRH analogues fact or fiction
- Central and peripheral effects of different analogues
- Clinical impact of different analogues due to their chemical nature and
delivery system
- New Indications for the use of GnRH Analogues
- Pharmacokinetic characteristics of GnRH Antagonist
- Pharmacodynamics of GnRH Analogues (Agonists and Antagonists)
- BioPharmaceutical Studies (Agonists and Antagonists)
- Regulation of GnRH expression in intact and cancerous tissues
B. GnRH Analogues in Prostate Cancer
- Scopes and limits of endocrine management of prostatic cancer
- Combination of endocrine and nonendocrine treatment of prostate cancer
- Neo and Adjuvant Treatment of LHRH analogues in early prostate cancer
- Combination Therapy of LHRH analogues with chemotherapy in hormone refractory
PCA
- Intermittent Therapy for prostate cancer
- Total versus partial androgen blockade in advanced prostate cancer
- Results of treatment of metastatic cancer using GnRH analogues
- Development of LHRH antagonists in prostate cancer
- Conservative management of benign prostate hypertrophy: future aspects
- New perspectives in the treatment of prostate cancer
- Treatment of hormonerefractory prostate cancer
C. GnRH Analogues in Reproduction
- Modern concepts in ovarian stimulation
- The era of recombinant Gonadotropin
- Pharmacoeconomics as it pertains to the use of the GnRH antagonists
- Mechanisms of actions and perspectives of the use of GnRH antagonists in
women
- Clinical application of GnRH analogues in reproduction
- The use of GnRH antagonists in conjunction with oral contraceptives in ovarian
stimulation protocols
- Use of GnRH analogues in the overall management of polycystic ovarian disease
- Do GnRH analogues represent an effective adjunctive treatment of infertility
in polycystic ovarian disease?
- Use of GnRH analogues for invitro fertilization
- Will GnRH analogues help in diagnosis prevention and treatment of functional
ovarian cysts?
- Will application of GnRH analogues enable classification of stages and treatment
of some types of premature ovarian failure?
- Results of GnRH antagonists in IVF
- Results of Dosefinding of GnRH antagonists
- Studies of Multiple Dose protocols of GnRH antagonists
- Optimization of GnRH antagonists protocol
- Studies of Single Dose protocols of GnRH antagonists
- Use of GnRH agonists for triggering ovulation in GnRH antagonists protocols
- Minimization of OHSS in GnRH antagonist protocols
- Preservation of ovarian function and fertility in survivors of gonadotoxic
chemotherapy
- Results and followup of children born after GnRH antagonist therapy
D. GnRH Analogues in Benign Gynecological Diseases
- Is there a role for GnRH antagonists in the management of endometriosis
- Longterm results with GnRH analogues in the treatment of endometriosis
- Early treatment of GnRH analogues in the treatment of endometriosis
- GnRH analogues in the management of Pelvic Pain
- The continuous benefit of GnRH analogues in the conservative treatment of
genital endometriosis
- Management of active and inactive Endometriosis
- Effects of GnRH antagonist on uterine leiomyoma growth and apoptosis
- The clinical value of long acting GnRH analogues (agonists and antagonists),
in the treatment of uterine fibroids
- The use of GnRH analogues for dysfunctional uterine bleeding
- Adverse effects of LHRH on mineral density: Possible therapies
E. GnRH Agonists in Ovarian and Breast Cancer
- The use of GnRH agonists and antagonists in the management of ovarian cancer
- The use of GnRH agonists and antagonists in the management of breast cancer
- The application of GnRH analogues in the management of endometrial cancer
- The use of GnRH agonists and antagonists in the management of other cancers
- The combined use of GnRH analogues and somatostatin in the management of
cancer
- The combination use of GnRH analogues and other therapeutic measures in
the management of cancer
- The potential diagnostic application of GnRH antagonists in mammography
F. 25th Anniversay of GnRH Agonists in Prostate Cancer
- Mode of Application of GnRHAgonists for the Treatment of Benign and Malignant
Diseases
- Epidemiology
- Scopes and limits of endocrine management of prostate cancer
G. GnRH Analogues in Contraception
- Animal models for testing GnRH analogues in female reproduction
- Peptide contraception by inhibition of ovulation using GnRH analogues
- Animal models for testing GnRH analogues in male reproduction
- The use of GnRH analogues in male contraception
H. GnRH Analogues in Male Indication
I. Safety
- Bone density changes associated with GnRH analogues
- Management of postmarketing surveillance following short and longterm use
of GnRH analogues
- Recovery of hormone secretion following longterm GnRH analogue treatment
- The longterm effect on fertility and bone mass following chronic long lasting
GnRH analogues treatment in children
- Safety of short and longterm treatment with GnRH analogues
- Safety of GnRH antagonists for mother and child
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