Chairpersons:
Jean F Bach , Paris, France
Manuel
Pascual, Boston, MA, USA
| 8:30 - 9:00 | NEW
STRATEGIES TO PREVENT GRAFT -VERSUS-HOST DISEASE
Marina
Cavazzana-Calvo, Isabelle Andre-Schmutz, Salima Hacein-Bey-Abina, Francoise
Le Deist, Alain Fischer, Paris, France | | 9:00
- 9:30 | THE MINI-TRANSPLANT CONCEPT AND ITS RELEVANCE
TO NON-MALIGNANT DISEASES
Yair Reisner
Rehovot, Israel | | 9:30
- 10:00 |
INDUCTION OF MIXED CHIMERISM IN CLINICAL TRANSPLANTATION
Manuel
Pascual Boston, USA | | 10:00
- 10:30 | COFFEE BREAK
| | 10:30 - 11:00 |
LONG TERM FOLLOW UP OF AUTOLOGOUS STEM CELL TRANSPLANTATION FOR REFRACTORY JUVENILE
IDIOPATHIC ARTHRITIS (JIA)
Nico Wulffraat,
Isme De Kleer, Danielle Brinkman, Wietse Kuis, Utrect, Netherlands |
| 11:00 - 11:30 | IMMUNE
INTERVENTION IN EARLY DIABETES
Jean F Bach,
Paris, France | | 11:30 -
12:00 | THERAPEUTIC
POTENTIALS OF CD4+CD25+ REGULATORY T CELLS
Benoît
L. Salomon Paris, France |
| 12:00 – 12:20 |
POLYCLONAL ANTIBODIES BLOCK EARLY ADHESION ON ENDOTHELIAL CELLS
Claus Hammer Munich, Germany | |
12:20 – 12:40 | LOW DOSE POLYCLONAL ANTIBODIES SUCCESFULLY
REVERSE REJECTION
Shamir Lustig Petach
Tikva, Israel | | 12:40 –
13:00 | PROSPECTIVE RANDOMIZED COMPARISON OF POLYCLONAL
VS. MONOCLONAL ANTIBODIES IN IMMUNOLOGICAL HIGH RISK PATIENTS
Professor Steiger Basle, Switzerland | |
13:00 – 13:20 | SINGLE HIGH DOSE ADMINISTRATION OF
POLYCLONAL ANTIBODIES IMPROVES THE OUTCOME OF RENAL TRANSPLANTATION
Narayanan Nampoory Safat, Kuwait | | 13:00
- 14:30 | LUNCH BREAK |
Chairpersons:
Ronald D. Guttmann, Montreal, Canada
Alexander
Yussim, Petach Tikva, Israel
| 14:30 - 14:40
| LONG-TERM RESULTS
OF A PROSPECTIVE RANDOMISED TRIAL OF CYCLOSPORIN MONOTHERAPY VERSUS CYCLOSPORIN
PLUS MMF IN CADAVERIC RENAL TRANSPLANT RECIPIENTS.
Manal
Kumar Ajay Sharma Abdel Hammad Geoff Owens Josep Grynio Robert Sells
Liverpool, UK; Llarge, Spain | | 14:40
- 14:50 |
COMPARATIVE ANALYSIS OF BASILIXIMAB VERSUS MYCOFENOLATE MOFETIL ADDITION TO CYCLOSOPRINE
BASED IMMUNOSUPPRESSION FOR THE PREVENTION OF ACUTE REJECTION IN PRIMARY KIDNEY
TRANSPLANTED PATIENTS
Adam Remport
Ildiko Sasvari Eva Toronyi Eniko Sarvary Viola Weszelits Norbert Lazar Jeno Jaray
Ferenc Perner Budapest,Hungary | | 14:50
- 15:00 |
SIMULECT FACILITATES STEROID WITHDRAWAL AFTER RENAL TRANSPLANTATION: RESULTS OF
AN ITALIAN, MULTICENTRE, PLACEBO-CONTROLLED STUDY.
Silvio
Sandrini Luca Arisi Gaetano Rizzo Umberto Valente Giuseppe La Greca
Gilberto Calconi Donato Donati Rosario Maiorca Roberto Ferrara Giuseppe Corbetta
Brescia, Italy; Parma, Italy; Pisa, Italy; Genova, Italy; Vicenza, Italy; Treviso,
Italy; Varese, Italy; Origgio VA, Italy | | 15:10 -
15:20 | EVALUATION
OF THE STEROID SPARING POTENTIAL OF TACROLIMUS
Heide
Sperschneider Domingo Del Castillo Caba Jena, Germany; Cordoba, Spain |
| 15:20 - 15:30 |
FIVE-YEAR-RESULTS OF A RANDOMIZED STUDY COMPARING FK506/MMF AND CICLOSPORIN A/AZATHIOPRINE
AFTER SIMULTANEOUS PANCREAS AND KIDNEY TRANSPLANTATION
Guido
Woeste Christoph Wullstein Olaf Pridöhl Kai Dette Wolf O. Bechstein
Bochum, Germany | | 15:30
- 15:40 |
THREE-YEAR EFFECTIVENESS OF AN ANTITHYMOCYTE GLOBULIN INDUCTION /CORTICOSTEROID-FREE
REGIMEN AFTER SIMULTANEOUS PANCREAS-KIDNEY TRANSPLANTATION
D.
Cantarovich G. Karam M. Giral M. Hourmant J. Dantal G. Blancho E. Franchimont
J.P. Soulillou Nantes France; Lyon France | | 15:40
- 15:50 | EFFECTS
OF A SIMULECT-BASED, STEROID-FREE IMMUNOSUPPRESSIVE REGIMEN IN HCV+ DE NOVO LIVER
TRANSPLANT PATIENTS
Gianluca G.L.G. Grazi
Marco M.C. Castagneto Fabrizio F.B. Bresadola Domenico D.F. Forti Roberto R.P.
Pisati Roberto R.F. Ferrara Mauro M.S. Salizzoni Bologna, Italy; Roma, Italy;
Udine, Italy; Milano, Italy; Origgio (Va), Italy; Torino, Italy |
| 15:50 - 16:00 | MMF
TREATMENT IN PATIENTS WITH HCV REINFECTION AFTER LIVER TRANSPLANTATION: INFLUENCE
ON CLINICAL COURSE AND HISTOLOGICAL DAMAGE
Marcus
Bahra Ulf P. Neumann Jan M. Langrehr Martin Harren Dietmar Jacob Thomas
Berg Ruth Neuhaus Peter Neuhaus Berlin, Germany | |
16:00 - 16:10 | EFFICACY
OF TACROLIMUS IN THE MANAGEMENT OF HIGH - RISK CORNEAL GRAFTS
A.
Joseph D. Raj R.J. Powell H.S. Dua Nottingham, UK | |
16:10 - 16:20 |
RANDOMIZED MULTICENTER PROSPECTIVE CLINICAL TRIAL ON THE EFFICACY OF MYCOPHENOLATE
MOFETIL IN COMPARISON TO METHOTREXATE FOR THE PROPHYLAXIS OF ACUTE GVHD IN STEM
CELL TRANSPLANT RECIPIENTS
Michael Kiehl
Karin Schaefer-Eckart Jochen Kienast Martin Bornhaeuser Hannes Wandt Andreas Jenke
Igor Blau Maria Shipkova Nadesta Basara Victor Armstrong Idar-Oberstein, Germany;
Nuernberg, Germany; Muenster, Germany; Dresden, Germany; Berlin, Germany; Goettingen,
Germany | | 16:20 - 16:30
| PHASE 1 AND 2 CLINICAL
TRIAL RESULTS OF ISATX247: NOVEL CALCINEURIN INHIBITOR
Mark D. Abel Launa
J. Aspeslet Anthony P. Broski Derrick G. Freitag Selvaraj S. Naicker Daniel J.
Trepanier Robert T. Foster Randall W. Yatscoff
Edmonton, Canada | | 16:30
- 17:00 | COFFEE BREAK |
Chairpersons:
Margreet Jonker,
Rijswijk, Netherlands
Stuart Knechtle,
Madison, USA
| 14:30 - 14:40 |
ROLE OF TGF-B1 CODON 10 AND CODON 25 POLYMORPHISM ON THE TGF-B1 GENE EXPRESSION
IN STABLE RENAL TRANSPLANTED PATIENTS
Andreas
Knoflach Zhongning Guo Ulrich Binswanger Zurich, Switzerland |
| 14:40 - 14:50 |
REGULATION OF T CELL AND MONOCYTE ACTIVATION BY HUMAN ANERGIC/SUPPRESSIVE CD4+CD25+
T CELLS
Leonie S. Taams Jocea M.R.
van Amelsfort Kim M.G. Jacobs Johannes W.J. Bijlsma Floris P.J.G. Lafeber Utrecht,
Netherlands | | 14:50 - 15:00
| HUMAN CD4+CD25+
T CELLS REGULATE CD8+ T CELL ACTIVATION
Niels
OS Camara Wan-Fai Ng Maria Hernandez-Fuentes Efren Eren Robert Lechler
London, UK | | 15:00 - 15:10
| ADOPTIVE TRANSFER
OF REGULATORY T CELLS FOLLOWING CHRONIC ALLOGRAFT REJECTION INDUCES TOLERANCE
FOR SECONDARY RENAL ALLOGRAFTS
Holger Schmidt
Alexander Filatenkow Anja Reutzel-Selke Martina Seifert Cornelia Doebis Anke Jurisch
Johann Pratschke Peter Neuhaus Stefan G. Tullius
Hans-Dieter Volk Berlin,
Germany; | | 15:10 - 15:20
| CD4+CD25+ IMMUNOREGULATORY
T-CELLS: A NEW THERAPEUTIC FOR GRAFT-VERSUS -HOST DISEASE
José
L. Cohen Douglas Vasey David Klatzmann Benoît L. Salomon Paris,
France | | 15:20 - 15:30
| ANTI-CD25 THERAPY
ALSO BLOCKS IL-4 PRODUCTION AFTER CLINICAL HEART TRANSPLANTATION: RESULTS OF ELISPOTS
AND REAL-TIME PCR ANALYSIS
Nicole M. van Besouw
Aggie H.M.M. Balk Wendy Mol Marleen van Vliet Teun van Gelder Carla C. Baan Willem
Weimar Rotterdam, Netherlands | | 15:30
- 15:40 | ANTI-CD25
THERAPY AFFECTS THE DEATH SIGNALS OF ACTIVATED T-CELLS AFTER CLINICAL HEART TRANSPLANTATION
Carla Baan Aggie Balk Wendy Mol Iza van Riemsdijk
Ronella de Kuiper Teun van Gelder Lex Maat Willem Weimar Rotterdam, Netherlands
| | 15:40 - 15:50 |
THERAPEUTIC EFFECT OF LF 15-0195 ON RAT EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
: INVOLVEMENT OF ANTIGEN SPECIFIC REGULATORY CELLS
Valerie
Duplan Patrick Dutartre Philippe Druet Abdelhadi Saoudi Toulouse, France;
Daix, France | | 15:50 - 16:00
| PERI-TRANSPLANT
DONOR SPECIFIC TRANSFUSION COMBINED WITH ANTI-CD4 AND CYCLOSPORINE INDUCTION THERAPY
PROLONGS FOETAL RAT PANCREAS ALLOGRAFT SURVIVAL.
Christo
J.F. Muller Don F. Du Toit Ben J. Page Johannes J. Matthyse Romeo F.C.
Lyners Tygerberg, South Africa | | 16:00
- 16:10 | SOLUBLE
HLA CLASS I MOLECULES. A NEW POTENTIAL IMMUNOSUPPRESSIVE TOOL ?
Paola
Contini Alessandro Poggi Massimo Ghio Francesco Indiveri Francesco
Puppo Genova, Italy | | 16:10
- 16:20 | DENDRITIC
CELLS 'PROHIBITED' BY ANERGIC T CELLS ACQUIRED 'TOLEROGENIC' PROPERTIES
Francisco Salcido-Ochoa Robert I. Lechler
London, UK | | 16:20 - 16:30
| GRAFT IMMUNOMODULATION
AND TOLERANCE ENHANCING STRATEGY FOR INTESTINAL TRANSPLANTATION
Kareem
Abu-Elmagd Geoffrey Bond Noriko Murase Jorge Reyes Anthony Demetris
Tong Wu John Fung Thomas Starzl Pittsburgh, USA | |
16:30 - 17:00 | COFFEE
BREAK |
Chairpersons:
Paul Mohacsi, Bern,
Switzerland
Randall Morris, Stanford,
USA
| 17:40 - 17:50 |
ACTIVITY OF MALONONITRILAMIDE COMPOUNDS AGAINST MURINE AND SIMIAN POLYOMAVIRUS
R. Snoeck G. Andrei H.S. Lilja W. Fitzsimmons
E. De Clercq
Leuven, Belgium; Deerfield, USA | |
17:00 - 17:10 |
INITIAL ORGAN ENGRAFTMENT WITH A SHORT TERM LOW DOSE CYA TREATMENT INDUCES TOLERANCE
FOR CONSEQUITIVE GRAFTS IN A MODEL OF STRONG HISTOINCOMAPTIBILITY
Filatenkow
Alexander Holger Schmidt Anja Reutzel-Selke Martina Seifert Cornelia
Doebis Anke Jurisch Johann Pratschke Peter Neuhaus Hans-Dieter Volk Stefan Tullius
Berlin, Germany | | 17:10
- 17:20 | INHIBITION
OF AUTOIMMUNE DIABETES BY MYCOPHENOLATE MOFETIL IS ASSOCIATED WITH DOWN-REGULATION
OF TH1 CYTOKINE-INDUCED APOPTOSIS IN THE TARGET TISSUE
Stanislava
Stosic-Grujicic Danijela Maksimovic Djordje Miljkovic Vladimir Trajkovic
Marija Mostarica Stojkovic Belgrade, Yugoslavia | |
17:20 - 17:30 |
INSULIN SECRETION OF ISOLATED ISLETS TESTED IN VITRO WITH NEW IMMUNOSUPPRESSIVE
PROTOCOLS
Giovanni Dellagiacoma Chiara
Magagna Maurizio Rossi Roberto Vecchioni
Verona, Italy | |
17:30 - 17:40 |
INFLIXIMAB FOR REFRACTORY AUTOIMMUNE OCULAR INFLAMMATORY DISEASE
C.
Murphy W. Ayliffe J. O'Donnell A. Booth H. Jefferson P.A. Andrews D.
Jayne
Croydon, UK; Carshalton, UK | |
17:50 - 18:00 |
T CELL DEVELOPMENT IN PRIMARY CMV-INFECTION
Laila
Gamadia Ester Remmerswaal Jan Weel Rob Rentenaar Sugianto Surachno
Rene van Lier Ineke ten Berge Amsterdam, Netherlands | |
18:00 - 18:10 |
A NEW T CELL APOPTOSIS-INDUCING ANTIBODY
Rong-Hwa
Lin Yi-Fen Lu Min-Chuan Huang Chiu-Chen Huang Yating Chuang Hoting
Su Evelyn Chiang CH Hebert Wu Taipei, Taiwan/ROC | |
18:10 - 18:20 |
ALTERATIONS IN FAS-L EXPRESSION AND FUNCTION IN MONOCYTES CULTURED WITH IMMUNOSUPPRESSIVE
AGENTS
Carl Atkinson Nikki Dennett
Rita Barcia Susan Rhind-Tutt Judith Jones Julie McLeod John Wallwork Martin Goddard
Cambridge, UK; Bristol, UK | | 18:20
- 18:30 |
MEBAVIN, A NEW IMMUNOSUPPRESSANT
Aybek Madaminov
Feruza Sabirova Tashkent, Uzbekistan | |
18:30 - 18:40 |
PIRFENIDONE- A NOVEL PHARMACOLOGICAL APPROACH TO THE TREATMENT OF ALLOGRAFT VASCULOPATHY
Julian Waller Gareth Bicknell Solomon Margolin
Michael Nicholson Leicester, UK; Texas, USA |
Chairpersons:
Pekka Häyry, Helsinki, Finalnd
Claus Hammer, Munich, Germany
| 18:00 - 18:10
| EFFECT
OF RAPAMYCIN AND PREDNISOLONE IN DIFFERENTIATED THP-1 AND U937 CELLS
Yee
Yung Liew Iain J. Brogan Ian V. Hutchinson Manchester, UK; Macclesfield,
UK | | 17:00
- 17:10 | SIROLIMUS AMELIORATES
LATE CONSEQUENCES OF RENAL ISCHEMIC INJURY IN RAT
Ondrej
Viklicky Prague, Czech Republic | |
17:10 - 17:20 |
TUMOR NECROSIS FACTOR-MEDIATED (TNF-ALPHA) CELL DEATH IS ATTENUATED BY RETROVIRUS-MEDIATED
HUMAN HEME OXYGENASE (HHO-1) GENE TRANSFER INTO HUMAN MICROVESSEL ENDOTHELIAL
CELLS (HMEC)
Alvin Goodman Taketoshi
Kushida Nader Abraham, New York, USA | |
17:20 - 17:30 |
MATURATION OF HEPATIC DENDRITIC CELLS DURING ISCHEMIA REPERFUSION INJURY
Patrizia Loi Frederic Paulart Nathalie Nagy
Vincent Donckier Michel Goldman Veronique Flamand, Bruxelles, Belgium |
| 17:30 - 17:40
| TGF-BETA
1 GENE EXPRESSION IN STABLE RENAL TRANSPLANT RECIPIENTS: INFLUENCE OF TGF-BETA
1 GENE POLYMORPHISM AND IMMUNOSUPPRESSION
Susanna
Ochsner Zhongning Guo Ulrich Binswanger Andreas Knoflach Zuerich, Switzerland |
| 17:40 - 17:50
| MYCOPHENOLATE
MOFETIL FOR TREATMENT OF ONGOING OR CHRONIC REJECTIONS AFTER LIVER TRANSPLANTATION
Jochen Klupp Robert Pfitzmann Jan M. Langrehr
Ruth Neuhaus Guido Junge Utz Settmacher Thomas Steinmueller Peter Neuhaus Berlin,
Germany | | 17:50
- 18:00 |
SYNERGISTIC EFFECTS OF SIROLIMUS AND TACROLIMUS ARE PREFERENTIAL TO ITS COMBINATION
WIITH CYCLOSPORIN IN THE DEVELOPMENT OF INTIMAL HYPERPLASIA
Julian
Waller Gareth Bicknell Michael Nicholson Leicester UK |
| 18:10 - 18:20
| LEFLUNOMIDE
ANALOGUE FK778 IS VASCULOPROTECTIVE INDEPENDENT OF ITS IMMUNOSUPPRESSIVE EFFECT.
POTENTIAL APPLICATIONS FOR RESTENOSIS AND CHRONIC REJECTION.
Johanna
Savikko Eva von Willebrand Pekka Häyry, Helsinki, Finland |
| 18:20 - 18:30 |
CD40L BLOCKADE PREVENTS AUTOIMMUNE DIABETES
BY INDUCTION OF BITYPIC NK/DC REGULATORY CELLS
Matthias
G. von Herrath Angelika Jahreis Tom Wolfe Anna Hughes Bryan Coon Marianne
J.B. van Stipdonk Stephen P. Schoenberger Dirk Homann La Jolla, CA, USA; San Diego,
CA, USA |
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