Session Title: Poster Session 1
Category: Psychosocial determinants of self-management
Presentation Date: Friday, November 07, 2008
RELATIONSHIPS BETWEEN FOOD PREFERENCE, DEPRESSION AND INSULIN RESISTANCE IN HEALTHY MEN
L. Brunerova1, J. Potockova1, J. Horacek1, M. Andel2
1Charles University, 3rd Faculty of Medicine and Faculty Hospital, Prague, Czech Republic, 2Charles University, Psychiatric Centre Prague, 3rd Faculty of Medicine, Prague, Czech Republic
Background and aims: Higher anxiety/depression scores can be connected with food preference of carbohydrates, with increased insulin secretion and thus can lead to insulin resistance. We postulated two null“ hypotheses: 1. more depressive / anxious (still in the normal range) subjects do not differ in food preference from those less depressive. 2. more depressive /anxious do not differ in insulin resistence from those less depressive or anxious.
Methods: 31 healthy men (43,8±7years, BMI 26,7±5,2kg/m²) were involved in the study. The study protocol included filling in SCL-90 questionnaire, self-assessing questionnaires for depression (SDS) and anxiety (SAS), carbohydrate craving questionnaire (CCQ), 3-days diet records. 4-hours hyperinsulinemic euglycemic clamp on two insulin levels (1mU/kg/min and 10mU/kg/min) with calculating the metabolic clearance rate of glucose (MCR1, MCR2) and citaloprame challenge test with calculation of area under the curve for prolactine (AUC/PRL) were performed. For statistical analyses Student´s t-test and Spearman´s correlation coefficient were used.
Results: We observed positive correlation between SAS resp. SDS scores and intake of monocarbohydrates in food: r=0,44, p=0,02; resp. r=0,4, p=0,03. On the contrary negative correlation was observed between MCR2 and SAS resp. SDS scores: r=-0,38, p=0,04; r=-0,04, p= 0,03.
Conclusions: We have proved that the subjects with higher depression/anxiety scores prefer more carbohydrates in the food and are more insulin resistant in comparison with those less anxious or depressive.
The study was supported by VZ MSM 0021620814.